Browse our latest Genetics and Genomics articles

Page 23 of 143
    1. Evolutionary Biology
    2. Genetics and Genomics

    Epistasis facilitates functional evolution in an ancient transcription factor

    Brian PH Metzger, Yeonwoo Park ... Joseph W Thornton
    A complete mutational scan of a protein-DNA interface shows that pairwise epistatic interactions among amino acids determine a transcription factor's specificity for DNA and facilitate the evolution of new functions.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    MOB rules: Antibiotic Exposure Reprograms Metabolism to Mobilize Bacillus subtilis in Competitive Interactions

    Yongjin Liu, Sandra LaBonte ... Paul D. Straight
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    • Incomplete
    1. Structural Biology and Molecular Biophysics
    2. Genetics and Genomics

    The RNA-binding activity of the TRIM-NHL protein NHL-2 is essential for miRNA-mediated gene regulation

    Nasim Saadat, Rhys N. Colson ... Peter R. Boag
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Genetics and Genomics

    Uncharacterized yeast gene YBR238C, an effector of TORC1 signaling in a mitochondrial feedback loop, accelerates cellular aging via HAP4- and RMD9-dependent mechanisms

    Mohammad Alfatah, Jolyn Jia Jia Lim ... Frank Eisenhaber
    Revealing YBR238C's involvement in the TORC1–mitochondria feedback loop deepens our understanding of aging biology, emphasizing the TOMITO concept as a crucial mechanism in cellular aging regulation.
    1. Genetics and Genomics
    2. Neuroscience

    Metabolic and neurobehavioral disturbances induced by purine recycling deficiency in Drosophila

    Céline Petitgas, Laurent Seugnet ... Serge Birman
    Purine recycling deficiency triggers metabolic and neurological defects reminiscent of Lesch–Nyhan disease in Drosophila, paving the way for studying this disorder and carrying out drug screening in an invertebrate organism.
    1. Genetics and Genomics

    Mono-methylated histones control PARP-1 in chromatin and transcription

    Gbolahan Bamgbose, Guillaume Bordet ... Alexei Tulin
    Genome-wide PARP-1 binding analysis advances the understanding of molecular mechanisms governing gene regulation in response to developmental cues and environmental stressors.
    1. Cancer Biology
    2. Genetics and Genomics

    Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)

    Ting Zhang, Alisa Ambrodji ... Steven M Offer
    A genetic variant within a newly identified enhancer regulates the expression of a key pharmacogene and alters the balance between resistance and sensitivity to a widely used chemotherapeutic.
    1. Genetics and Genomics

    Khdc3 Regulates Metabolism Across Generations in a DNA-Independent Manner

    Liana Senaldi, Nora Hassan ... Matthew Smith-Raska
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Imputation of 3D genome structure by genetic–epigenetic interaction modeling in mice

    Lauren Kuffler, Daniel A Skelly ... Gregory W Carter
    Genetic variants interact with open chromatin to alter gene expression within topologically associated domains of DNA in outbred mice.
    1. Genetics and Genomics
    2. Neuroscience

    Genetic Chimerism: Marmosets contain multitudes

    Kenneth Chiou, Noah Snyder-Mackler
    Single-cell RNA sequencing reveals the extent to which marmosets carry genetically distinct cells from their siblings.
    Version of Record
    Insight