Browse our latest Genetics and Genomics articles

Page 24 of 147
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Ethnic and region-specific genetic risk variants of stroke and its comorbid conditions can define the variations in the burden of stroke and its phenotypic traits

    Rashmi Sukumaran, Achuthsankar S Nair, Moinak Banerjee
    Genomic differences in stroke and its comorbid conditions can aid in refining the socio-economic interpretation of risk among different ethnicities and can assist in distinguishing their phenotypic variation.
    1. Genetics and Genomics

    Dysfunction of Calcyphosine-Like gene impairs retinal angiogenesis through the MYC axis and is associated with familial exudative vitreoretinopathy

    Wenjing Liu, Shujin Li ... Xianjun Zhu
    Genetic analysis and knockout mouse model study identified calcyphosine-like (CAPSL) as a candidate disease gene in familial exudative vitreoretinopathy (FEVR), offering valuable insights into disease mechanisms.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The protein domains of vertebrate species in which selection is more effective have greater intrinsic structural disorder

    Catherine A Weibel, Andrew L Wheeler ... Joanna Masel
    Proteins evolve more intrinsic structural disorder under more effective selection, with selection assessed via a novel metric of codon adaptation.
    1. Developmental Biology
    2. Genetics and Genomics

    Early moderate prenatal alcohol exposure and maternal diet impact offspring DNA methylation across species

    Mitchell Bestry, Alexander N Larcombe ... David Martino
    Early moderate consumption of alcohol in pregnancy was sufficient to disrupt the fetal epigenome in newborn mice, and high folate maternal diets had a mitigating effect.
    1. Developmental Biology
    2. Genetics and Genomics

    PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development

    Julia Raulino Lima, Nicha Ungvijanpunya ... Jian Xu
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Developmental Biology
    2. Genetics and Genomics

    Ripply1 and Gsc collectively suppress anterior endoderm differentiation from prechordal plate progenitors

    Tao Cheng, Xiang Liu ... Peng-Fei Xu
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Genetics and Genomics

    Resetting of H3K4me2 during mammalian parental-to-zygote transition

    Chong Wang, Yong Shi ... Jiawei Xu
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during Caenorhabditis elegans meiosis

    Erik Toraason, Alina Salagean ... Diana E Libuda
    To maintain genomic integrity during oocyte development, the tumor suppressor BRCA1/BRC-1 and the SMC-5/6 complex both repress intersister crossover recombination events while BRCA1/BRC-1 also specifically inhibits error prone repair of DNA breaks during meiotic prophase I.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Transposon mutagenesis screen in Klebsiella pneumoniae identifies genetic determinants required for growth in human urine and serum

    Jessica Gray, Von Vergel L Torres ... Ian R Henderson
    Klebsiella pneumoniae has specific repertoires of genes required for growth in urine and serum, highlighting new targets for antimicrobial treatments of this important pathogen.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A single-cell atlas of the miracidium larva of Schistosoma mansoni reveals cell types, developmental pathways, and tissue architecture

    Teresa Attenborough, Kate A Rawlinson ... Matthew Berriman
    A comprehensive description of gene expression and organisation in the cells that constitute the blood fluke larvae responsible for finding and invading its intermediate host.