Browse our latest Genetics and Genomics articles

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    1. Cell Biology
    2. Genetics and Genomics

    Mechanistic insights into transcriptional regulation of ARHGAP36 expression identify a factor predictive of neuroblastoma survival

    Serhiy Havrylov, Armin M Gamper, Ordan J Lehmann
    Genetic experiments integrated with ChIP-sequencing and CRISPR interference reveal that overexpression of Foxc1 transcriptionally activates the expression of Arhgap36 and dysregulates multiple facets of Hedgehog pathway activity.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Intersecting experimental evolution and CRISPR screens to identify novel toxin resistance loci

    Michele Marconcini, Steeve Cruchet ... Richard Benton
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics

    Abundant Parent-of-origin Effect eQTL: The Framingham Heart Study

    Yongtao Guan, Tianxiao Huan, Daniel Levy
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Genetics and Genomics

    A pilot study for whole proteome tagging in Caenorhabditis elegans

    Matthew Eroglu, Oliver Hobert
    Simultaneous tagging of multiple genes with different fluorophores provides a proof of concept for the scalability of tagging all genes in the Caenorhabditis elegans genome.
    1. Genetics and Genomics
    2. Neuroscience

    Dominant α-tubulin mutations rescue tauopathy neurodegenerative phenotypes in C. elegans

    Sarah J Benbow, Aleen D Saxton ... Brian C Kraemer
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Genetics and Genomics

    Mutational and Expression Profile of ZNF217, ZNF750, ZNF703 Zinc Finger Genes in Kenyan Women Diagnosed with Breast Cancer

    Michael Kitoi, John Gitau ... Francis Makokha
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Evolutionary Biology
    2. Genetics and Genomics

    Constraints on the G1/S transition pathway may favor selection of multicellularity as a passenger phenotype

    Tom Louis Ducrocq, Damien Laporte, Bertrand Daignan-Fornier
    A genetic analysis in yeast establishes that multicellularity can arise as a side-effect (passenger phenotype) of a completely independent fitness advantage unrelated to the benefits of group formation itself.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome reorganization and its functional impact during breast cancer progression

    Kathleen S Metz Reed, Andrew Fritz ... Tom Misteli
    Genome-wide maps of chromatin structure in a cell-based model of breast cancer reveal chromatin reorganization accompanied by changes in transcription and epigenetic marks.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Faroese whole genomes provide insight into ancestry and recent selection

    Iman Hamid, Ólavur Mortensen ... Noomi O Gregersen
    Present-day Faroese genomes reveal ancestry, bottleneck history, and signatures of selection, and offer a foundation for understanding the genetic architecture of health and disease in this North Atlantic founder population.
    1. Genetics and Genomics

    A systematic interactome of SET1C expands its functional landscape and identifies candidate regulatory connections

    Pierre Luciano, Kihyun Park ... Vincent Géli
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
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