Browse our latest Genetics and Genomics articles

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    1. Genetics and Genomics

    Expanding the Drosophila toolkit for dual control of gene expression

    Jonathan Zirin, Barbara Jusiak ... Norbert Perrimon
    A CRISPR knock-in approach enables the efficient generation of tissue-specific LexA and QF driver lines which can simultaneously control gene expression in multiple tissues.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Immune Response: Investigating the role of vitamin D in asthma

    Siddhant Sharma, Mayank Garg
    Results in mice suggest that vitamin D reduces the symptoms of asthma by controlling an immune response that leads to inflammation of the airways.
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    1. Genetics and Genomics
    2. Immunology and Inflammation

    Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1

    Ayse Kilic, Arda Halu ... Scott T Weiss
    Vitamin D regulates two human chromosomal loci, Chr17q12-21.1 and Chr17q21.2, that are associated with autoimmune and chronic inflammatory diseases.
    1. Genetics and Genomics

    Meta-Research: Understudied genes are lost in a leaky pipeline between genome-wide assays and reporting of results

    Reese Richardson, Heliodoro Tejedor Navarro ... Thomas Stoeger
    Find My Understudied Genes (FMUG) is a data-driven tool created to counteract the abandonment of understudied genes in -omics research.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal care

    Xinjian Ye, Yijing Bai ... Qianming Chen
    Mendelian randomization and transcriptome-wide association studies delineate the causal relationships and genetic markers between circulating immune cells and periodontitis, pinpointing neutrophils as the predominant contributors.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Vascular Endothelium: More than just a simple barrier

    Erandi Velazquez-Miranda, Ming He
    Endothelial cell subpopulations are characterized by unique gene expression profiles, epigenetic landscapes and functional properties.
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    1. Genetics and Genomics

    Comprehensive mutagenesis maps the effect of all single-codon mutations in the AAV2 rep gene on AAV production

    Nina K Jain, Pierce J Ogden, George M Church
    Measurement of the effect of all single-codon variants of the AAV2 rep gene on recombinant adeno-associated virus production identifies novel beneficial variants, which may facilitate improvement of gene therapy production.
    1. Developmental Biology
    2. Genetics and Genomics

    Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy

    Zian Liao, Suni Tang ... Martin Matzuk
    Mouse models reveal fundamental roles of SMAD1/5 in mediating both bone morphogenetic protein signaling pathways and the transcriptional response to progesterone during decidualization.