Browse our latest Genetics and Genomics articles

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    1. Evolutionary Biology
    2. Genetics and Genomics

    Faroese whole genomes provide insight into ancestry and recent selection

    Iman Hamid, Ólavur Mortensen ... Noomi O Gregersen
    Present-day Faroese genomes reveal ancestry, bottleneck history, and signatures of selection, and offer a foundation for understanding the genetic architecture of health and disease in this North Atlantic founder population.
    1. Genetics and Genomics

    A systematic interactome of SET1C expands its functional landscape and identifies candidate regulatory connections

    Pierre Luciano, Kihyun Park ... Vincent Géli
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Incomplete
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Methylation Clocks Do Not Predict Age or Alzheimer’s Disease Risk Across Genetically Admixed Individuals

    Sebastián Cruz-González, Ogechukwu Okpala ... John A Capra
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics

    Optimised genome editing for precise DNA insertion and substitution using Prime Editors in zebrafish

    Yosuke Ono, Martin Peterka ... Steffen Scholpp
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Genetics and Genomics
    2. Evolutionary Biology

    Most Beefalo cattle have no detectable bison genetic ancestry

    Beth Shapiro, Jonas Oppenheimer ... Timothy PL Smith
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease

    Conor J Howard, Nathan S Abell ... Diane E Dickel
    A comprehensive mutational scan of TYK2 identifies novel allosteric sites, elucidates functional drug-protein interactions, and links autoimmune disease protection to reduced TYK2 protein abundance.
    1. Developmental Biology
    2. Genetics and Genomics

    PIK3CA-related overgrowth spectrum (PROS) zebrafish models reveal pan-lineage developmental dysregulation

    Hannah Brunsdon, Nuoya Wang ... E Elizabeth Patton
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling

    Kasturi Biswas, Caroline Moore ... Michael M Francis
    Muscarinic cholinergic signaling links neural activity to organism‑wide transcriptional and proteostatic responses that protect against chronic oxidative stress.
    1. Genetics and Genomics

    Autosomal Allelic Inactivation: Variable Replication and Dosage Sensitivity

    Michael B Heskett, Athanasios E Vouzas ... Mathew J Thayer
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Genetics and Genomics
    2. Neuroscience

    Learning is a fundamental source of individuality

    Riddha Manna, Johanni Brea ... Ana Marija Jakšić
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
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