Sarah E Sandkuhler, Kayla S Youngs ... Samuel J Mackenzie
Evidence from multiple model systems supports a shift away from heme transport and toward metabolic dysfunction and oxidative stress as key drivers of TANGO2 deficiency.
A replication stress–ELF3 axis enables luminal progenitor transformation in BRCA1-deficient breast cancer by reducing genomic instability and promoting progenitor identity.
Experiments reveal that a time-dependent epistatic interaction influences how mice respond to opioids, and that intracellular fibroblast growth factors also influence opioid sensitivity.
Álvaro Escobar Doncel, Constantinos Patinios ... Colin J Ingham
Disrupting a single molybdenum cofactor gene allowed us to connect metabolic regulation of complex carbohydrates with cell organization, enabling genetic tuning of bacterial structural color for biomaterial applications.
