Browse our latest Genetics and Genomics articles

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    1. Evolutionary Biology
    2. Genetics and Genomics

    Balancing selection on genomic deletion polymorphisms in humans

    Alber Aqil, Leo Speidel ... Omer Gokcumen
    1. Genetics and Genomics

    Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors

    Joseph M Replogle, Jessica L Bonnar ... Marco Jost
    Newly developed, highly active CRISPR interference single guide RNA libraries and effectors together enable high-quality genetic screens across cell models.
    1. Genetics and Genomics

    Generating colorblind-friendly scatter plots for single-cell data

    Tejas Guha, Elana J Fertig, Atul Deshpande
    scatterHatch helps users generate colorblind-friendly scatter plot visualizations by using a combination of patterns and high-contrast colors to represent distinct point groups.
    1. Genetics and Genomics
    2. Structural Biology and Molecular Biophysics

    Structure-guided isoform identification for the human transcriptome

    Markus J Sommer, Sooyoung Cha ... Steven L Salzberg
    The ability to accurately predict a protein's structure gives us an entirely new way to annotate the human genome.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Heritability enrichment in context-specific regulatory networks improves phenotype-relevant tissue identification

    Zhanying Feng, Zhana Duren ... Yong Wang
    Integrating chromatin accessibility and gene expression data into context-specific regulatory networks can provide better regulatory categories for heritability enrichment and relevant tissue identification.
    1. Genetics and Genomics
    2. Neuroscience

    Monoallelic CRMP1 gene variants cause neurodevelopmental disorder

    Ethiraj Ravindran, Nobuto Arashiki ... Angela M Kaindl
    Genetic finding of pathogenic CRMP1 variants in three unrelated individuals with neurodevelopmental disorder, supported by structural simulation, biochemical and proof-of-principle data highlights the key role of CRMP1 in the development and functioning of the nervous system in humans.
    Short Report Updated
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    1. Evolutionary Biology
    2. Genetics and Genomics

    Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness

    Amanda Kowalczyk, Maria Chikina, Nathan Clark
    Studying the genomes of mammals with sparse hair covering identifies specific genes and regulatory regions responsible for the formation of hair and skin, some of which were previously unrecognized.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    m6A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5’ splice site

    Matthew T Parker, Beth K Soanes ... Gordon G Simpson
    High throughput sequencing of Arabidopsis mutants lacking the U6 snRNA methyltransferase FIONA1/METTL16 uncovers the role of U6 methylation in splicing signal preferences.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolution: How (some) mammals lost their hair

    Matthew D Dean
    An approach that allows scientists to identify regions of the genome that evolved faster in hairless mammals reveals candidate genetic mechanisms that gave rise to hairlessness.
    Insight
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    1. Evolutionary Biology
    2. Genetics and Genomics

    Comparative genomics reveals insight into the evolutionary origin of massively scrambled genomes

    Yi Feng, Rafik Neme ... Laura F Landweber
    The comparison of three ciliate species that share complex pathways for natural genome editing allows capture of intermediate states in the acquisition of scrambled genes and elucidating a pathway for the origin and evolution of extremely rearranged chromosomes.