Browse our latest Genetics and Genomics articles

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    1. Genetics and Genomics
    2. Neuroscience

    Rescue of behavioral and electrophysiological phenotypes in a Pitt-Hopkins syndrome mouse model by genetic restoration of Tcf4 expression

    Hyojin Kim et al.
    Normalizing Tcf4 expression during early postnatal development improves behavioral outcomes in Pitt-Hopkins syndrome (PTHS) model mice, suggesting that genetic therapies are feasible in individuals with PTHS.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    History-dependent physiological adaptation to lethal genetic modification under antibiotic exposure

    Yuta Koganezawa et al.
    Single-cell time-lapse imaging and optogenetical gene recombination system uncovered that bacteria cells can overcome a deleterious genetic change of antibiotic resistance gene deletion depending on their environmental histories.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Parent-of-origin effects propagate through networks to shape metabolic traits

    Juan F Macias-Velasco et al.
    Non-imprinted genes can contribute to parent-of-origin effects on phenotype through interactions with imprinted genes.
    1. Cancer Biology
    2. Genetics and Genomics

    Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs

    Antonio Cuevas-Navarro et al.
    Biochemical and genetic analysis of the functional relationship between RIT1 and its regulatory protein, LZTR1, across various model organisms helps define the substrate specificity of LZTR1 for RAS GTPases.
    1. Genetics and Genomics

    Boosting targeted genome editing using the hei-tag

    Thomas Thumberger et al.
    Increased efficiency of targeted genome editing by simple addition of a bipartite-optimized tag at the N- and C-termini of effector proteins (Cas9 and cytosine-to-thymine base editor) is applicable in organismo and cell culture.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Contingency and selection in mitochondrial genome dynamics

    Christopher J Nunn, Sidhartha Goyal
    Single-molecule sequencing and mating experiments in yeast reveal key properties of mitochondrial DNA dynamics that inform the fate of mutant mtDNA in cells.
    1. Genetics and Genomics
    2. Medicine

    Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study

    Fernanda Morales Berstein et al.
    GrimAge acceleration may increase the risk of colorectal cancer.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genetic loci and metabolic states associated with murine epigenetic aging

    Khyobeni Mozhui et al.
    Age-dependent changes in DNA methylation are tightly coupled to the metabolic state, and is partly under genetic regulation, and longer lifespan is associated with lower epigenetic entropy at CpGs that increase in methylation with age.
    1. Genetics and Genomics
    2. Medicine

    Cancer: The aging epigenome

    Brandon L Pierce
    A new approach helps to assess the impact of accelerated epigenetic aging on the risk of cancer.
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