Browse our latest Genetics and Genomics articles

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    1. Genetics and Genomics
    2. Neuroscience

    Molecular and spatial transcriptomic classification of midbrain dopamine neurons and their alterations in a LRRK2G2019S model of Parkinson’s disease

    Zachary Gaertner, Cameron Oram ... Rajeshwar Awatramani
    A high-resolution atlas of the mouse dopaminergic system was obtained using single-nuclei RNA sequencing and spatial transcriptomics revealing molecular changes in a prodromal model of Parkinson's disease.
    1. Developmental Biology
    2. Genetics and Genomics

    Genetic evidence: zebrafish hoxba and hoxbb clusters are essential for the anterior-posterior positioning of pectoral fins

    Morimichi Kikuchi, Renka Fujii ... Akinori Kawamura
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Genetics and Genomics

    Confirmation of HLA-II associations with TB susceptibility in admixed African samples

    Dayna Croock, Yolandi Swart ... Caitlin Uren
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics

    Ribosomal RNA synthesis by RNA polymerase I is regulated by premature termination of transcription

    Chaïma Azouzi, Katrin Schwank ... Christophe Dez
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology
    2. Genetics and Genomics

    DNA replication in primary hepatocytes without the six-subunit ORC

    Róża K Przanowska, Yuechuan Chen ... Anindya Dutta
    Mammalian cells are capable of loading MCM2-7 to support DNA replication in the absence of ORC to permit extensive DNA replication in vivo.
    1. Genetics and Genomics
    2. Neuroscience

    Antagonist actions of CMK-1/CaMKI and TAX-6/calcineurin along the C. elegans thermal avoidance circuit orchestrate adaptation of nociceptive response to repeated stimuli

    Martina Rudgalvyte, Zehan Hu ... Dominique A Glauser
    Phosphoproteomics identifies diverse CaM kinase substrates, while genetic dissection reveals an unexpected antagonistic interaction with calcineurin signaling that operates in distinct neurons to regulate thermo-nociception in Caenorhabditis elegans.
    1. Genetics and Genomics
    2. Medicine

    EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis

    Lianlei Wang, Xinyu Yang ... Nan Wu
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Genetics and Genomics

    IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming

    Mengjia Li, Hengchao Zhang ... Lixiang Chen
    Integrated multi-omics analyses reveal the metabolism-independent role of nuclear IDH1 in chromatin remodeling during human erythropoiesis.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Major nuclear locales define nuclear genome organization and function beyond A and B compartments

    Omid Gholamalamdari, Tom van Schaik ... Andrew S Belmont
    New insights into nuclear genome organization were generated by comparing genome localization relative to three major nuclear locales- nuclear lamina, nuclear speckles, and nucleoli- across several human cell lines.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Deep sequencing of yeast and mouse tRNAs and tRNA fragments using OTTR

    Hans Tobias Gustafsson, Lucas Ferguson ... Oliver J Rando
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