Inhibition of the UFD-1-NPL-4 complex activates immune responses in Caenorhabditis elegans that reduce gut pathogen load but simultaneously compromise host survival.
Primate cross-species analysis of interactions between transposable elements and KRAB-ZNF genes with the new TEKRABber tool highlights human-specific interactions with potential relevance to Alzheimer’s disease.
A Maxwell Burroughs, Gianlucca G Nicastro, L Aravind
A hitherto unrecognized superfamily of enzymes identified here provides unifying insights spanning lipid metabolism, anti-viral and anti-bacterial immunity, and the origin of developmental regulators like Wnt.
WRN and WRNP1 ATPases together with WRN 3’ to 5’ exonuclease raise the fidelity of intrinsically highly error-prone Y-family DNA polymerases such that they perform error-free translesion synthesis.
Shelby A Roseman, Allison P Siegenfeld ... Brian B Liau
CTCF binding promotes chromatin-nuclear speckle interactions and gene activation after DNA demethylation, yet its binding and looping patterns are unaffected by speckle depletion.
Amy K Webster, John H Willis ... Patrick C Phillips
Differences among genetically identical individuals can be explained using expression levels of just a handful of genes, suggesting that environmental variation can be functionally analyzed.
Connor Hill, Alexandra Indeglia ... Alessandro Gardini
Molecular profiling with omics approaches reveals the resemblance between neuroendocrine malignancies and solitary fibrous tumors, rare soft tissue cancers with no effective treatment options.
