Browse our latest Genetics and Genomics articles

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    1. Genetics and Genomics
    2. Neuroscience

    Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling

    Kasturi Biswas, Caroline Moore ... Michael M Francis
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Separable downmodulation of meiotic axis protein deposition and DNA break induction at chromosome ends

    Adhithi R Raghavan, Kieron May ... Andreas Hochwagen
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Neuroscience

    Acute opioid responses are modulated by dynamic interactions of Oprm1 and Fgf12

    Paige M Lemen, Yanning Zuo ... Hao Chen
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    1. Genetics and Genomics

    Mapping of in vivo cleavage sites uncovers a major role for yeast RNase III in regulating protein-coding genes

    Lee-Ann Notice-Sarpaning, Mathieu Catala ... Ambro van Hoof
    The yeast Drosha homolog Rnt1 has a major role in mRNA degradation.
    1. Genetics and Genomics

    Stranded short nascent strand sequencing reveals the topology of DNA replication origins in Trypanosoma brucei

    Slavica Stanojcic, Bridlin Barckmann ... Yvon Sterkers
    Replication origins in Trypanosoma brucei integrate multiple features previously described individually in opisthokonts, revealing a unified structural topology built from strand-specific nucleotide composition, G‑quadruplex enrichment, and distinctive nucleosome patterns.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    NK2R signaling governs intestinal lipid mobilization and mucosal inflammation

    Pedro A Perez, Chung-Chih Liu ... Supriya Srinivasan
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Genetics and Genomics
    2. Evolutionary Biology

    Ancestral secretory programs underlie the evolution of morphological innovations across Spiralia

    Yitian Bai, Kunyin Jiang ... Qi Li
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Genetics and Genomics

    Mutational and Expression Profile of ZNF217, ZNF750, ZNF703 Zinc Finger Genes in Kenyan Women Diagnosed with Breast Cancer

    Michael Kitoi, John Gitau ... Francis Makokha
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics

    Mettl5 coordinates protein production and degradation of PERIOD to regulate sleep in Drosophila

    Xiaoyu Wu, Xingzhuo Yang ... Juan Du
    The Mettl5/Trmt112 complex alters rRNA methylation, increasing PERIOD protein linking ribosome function, clock genes, and proteasome in sleep regulation in Drosophila.
    1. Genetics and Genomics
    2. Cancer Biology

    Functional characterization of a multi-cancer risk locus on chromosome band 2q33.1 near CASP8

    Hyunkyung Kong, Jiyeon Choi ... Kevin M Brown
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling