Adult Drosophila exposed to auxin at the recommended concentrations for the AGES transgene expression system display defects in feeding behavior, have altered metabolic transcripts, and have reduced triacylglyceride levels.
Dylan C Sarver, Jean Garcia-Diaz ... G William Wong
Mice lacking Tmem263 are dwarfs, and this phenotype is associated with reduced hepatic growth hormone (GH) receptor expression, a deficit in GH-induced signaling, and low insulin-like growth factor 1 level.
Haiko Schurz, Vivek Naranbhai ... International Tuberculosis Host Genetics Consortium
Results from the largest tuberculosis genome-wide association study meta-analysis identified a significant association in the human leukocyte antigen class II region, rs28383206, across multiple populations.
Strong reduction in malaria transmission by genetically modified mosquitoes is achieved in the laboratory using a dual gene drive that simultaneously propagates an antiparasitic factor and a parasite-detrimental mosquito mutation.
A single-cell RNA profiling analysis has delineated the molecular changes driving the progression from actinic keratosis to cutaneous squamous cell carcinoma.
Alex Mas-Sandoval, Sara Mathieson, Matteo Fumagalli
Social hierarchies resulting from the European colonization of the Americas stratified the population structure, leading to ancestry-related assortative mating and sex bias patterns that can be inferred from the genomes of the populations across the continent.
A comparison between artificially created allopolyploids and natural ones reveals that the latter underwent significant evolutionary steps after their formation.
Elisabet Stener-Victorin, Gustaw Eriksson ... Anna Benrick
Elevated levels of ectopic fat and a decreased number of oxidative insulin-sensitive type I muscle fibers in skeletal muscle could lead to insulin resistance in women with polycystic ovary syndrome.
