The flexible stalk region of sTREM2 binds the Ig-like domain, altering stability and ligand accessibility—a biochemically testable mechanism with broad implications for (s)TREM2 biology and rational Alzheimer's disease therapeutic design.
Inhibition of the UFD-1-NPL-4 complex activates immune responses in Caenorhabditis elegans that reduce gut pathogen load but simultaneously compromise host survival.
Gut-to-brain communication via glial cytokine signaling links intestinal oxidative stress to altered sleep patterns, highlighting how gut inflammation can influence brain function and restorative sleep behaviors essential for mental well-being.
The kinase activity of Aurora kinase A is required for preserving S-adenosylmethionine availability for histone methylation and epigenetic reprogramming during trained immunity induction in macrophages.
sIgM plays a role in viral neutralization across both primitive and modern vertebrates by following conserved principles in the development of specialized antiviral immunity.
Brandon T Tran, Vidthiya Jeyanathan ... Katherine Y King
Inflammation supports selection, differentiation bias, and epigenetic reprogramming of hematopoietic stem and progenitor cells to generate innate immune memory.
Toll-like receptors (TLRs) shape trained immunity, balancing infection responses and chronic inflammation, and TLR agonists are promising immunomodulators for infectious diseases and cancer.
Engineering self-amplifying RNA to intrinsically disarm the innate immune pathways it triggers enables durable, externally controlled gene expression with reduced cytotoxicity and cytokine release, eliminating the need for exogenous immunosuppressants.
