Several studies have now demonstrated that trained immunity occurs in the airways to several pathogens and products, while its utility is yet to be determined.
Wesley H Godfrey, Judy J Lee ... Michael D Kornberg
The glycolytic enzyme phosphoglycerate mutase supports Treg function, identifying a novel therapeutic target for immune modulation and demonstrating that glycolytic regulation of T cells is more nuanced than previously appreciated.
Both adaptive and innate immune memory responses have been described in gamma delta T cells, yet the mechanisms, the ligands and the gamma delta T cell subsets generating memory responses have remain to be explored.
Hannah Riley Knight, Marie Kim ... Aaron Esser-Kahn
Current approaches in bioengineering are synthesized and methods for their implementation are suggested for the induction and modulation of trained immunity in the treatment of human diseases.
Interferon-γ and prostaglandin E2 signaling oppose each other to determine the balance between two distinct TNF-induced inflammatory gene expression programs relevant for rheumatoid and immune checkpoint inhibitor-induced arthritis.
