Browse our latest Immunology and Inflammation articles

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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis

    Wenn-Chyau Lee, Bruce Russell ... Laurent Renia
    Plasmodium parasites use host-derived factors to form more rosettes and hamper phagocytosis, representing a new escape mechanism for the malaria parasites.
    1. Cell Biology
    2. Immunology and Inflammation

    Microtubule plus-end dynamics link wound repair to the innate immune response

    Clara Taffoni, Shizue Omi ... Nathalie Pujol
    Microtubules orchestrate wound repair and innate immune response in the Caenorhabditis elegans epidermis.
    1. Immunology and Inflammation

    TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury

    Salik Hussain, Collin G Johnson ... Stavros Garantziotis
    The response to TLR4 ligands in mice and humans is modulated by TLR5, which participates in the TLR4 signaling complex.
    1. Immunology and Inflammation

    c-Maf restrains T-bet-driven programming of CCR6-negative group 3 innate lymphoid cells

    Caroline Tizian, Annette Lahmann ... Christian Neumann
    c-Maf is a novel key regulator of the type 3-to-1 conversion of CCR6– ILC3s that controls the functional plasticity of ILC3s by acting as a cell-intrinsic gatekeeper of T-bet expression.
    1. Immunology and Inflammation

    Neonatal-derived IL-17 producing dermal γδ T cells are required to prevent spontaneous atopic dermatitis

    Nicholas A Spidale, Nidhi Malhotra ... Joonsoo Kang
    Neonatal-origin dermal Tγδ17 cells are required to maintain normal keratinocytes and prevent spontaneous atopic dermatitis.
    1. Immunology and Inflammation

    High-dimensional analysis of intestinal immune cells during helminth infection

    Laura Ferrer-Font, Palak Mehta ... Johannes U Mayer
    A systematic optimization of intestinal digestion protocols allows for the isolation and high-dimensional flow cytometric analysis of intestinal immune cells during murine helminth infection.
    1. Immunology and Inflammation

    Endothelial heterogeneity across distinct vascular beds during homeostasis and inflammation

    Ankit Jambusaria, Zhigang Hong ... Jalees Rehman
    Vascular endothelial cells in the brain, heart and lung exhibit tissue-specific heterogeneity and plasticity, expressing genes that were traditionally thought to be only expressed by the surrounding parenchymal tissue cells.
    1. Immunology and Inflammation

    Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses

    Jihyung Lee, Junyan Zhang ... Eyal Raz
    Reprogramming of transcription factors by PRR-independent (cAMP) and PRR-dependent (curdlan) signaling induces new dendritic cell subset.
    1. Developmental Biology
    2. Immunology and Inflammation

    Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila

    Katrin Kierdorf, Fabian Hersperger ... Marc S Dionne
    A cytokine partly derived from macrophages is required to promote normal muscle health and metabolism by inhibiting the activity of the insulin signalling pathway in the fruitfly Drosophila melanogaster.
    1. Developmental Biology
    2. Immunology and Inflammation

    Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice

    Ken-ichi Hirano, Akiko Suganami ... Katsuto Hozumi
    Notch ligand, Dll4 needs the flexible loop structure in the MNNL domain of the extracellular region to efficiently trigger the Notch signaling.