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    1. Medicine
    2. Microbiology and Infectious Disease

    Neuroinfectiology of an atypical anthrax-causing pathogen in wild chimpanzees

    Tobias Gräßle, Carsten Jäger ... Markus Morawski
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Medicine

    Cbfβ regulates Wnt/β-catenin, Hippo/Yap, and Tgfβ signaling pathways in articular cartilage homeostasis and protects from ACLT surgery-induced osteoarthritis

    Wei Chen, Yun Lu ... Yi-Ping Li
    Low expression of Cbfb may be the cause of osteoarthritis, and local admission of Cbfb may rescue and protect against osteoarthritis through decreasing Wnt/β-catenin signaling, and increasing Hippo/Yap signaling and Tgfβ/Smad2/3 signaling in osteoarthritis articular cartilage.
    1. Genetics and Genomics
    2. Medicine

    Impaired central pattern generators due to abnormal EPHA4 signaling leads to idiopathic scoliosis

    Lianlei Wang, Sen Zhao ... Nan Wu
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Medicine
    2. Neuroscience

    Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model

    Yunlu Xue, Yimin Zhou, Constance L Cepko
    Multiple alleles of Txnip, which can interact with several different proteins, including Hsp90AB1, were tested for their ability to prolong the survival of cone photoreceptors in diseases leading to blindness.
    1. Medicine

    Fungal–bacteria interactions provide shelter for bacteria in Caesarean section scar diverticulum

    Peigen Chen, Haicheng Chen ... Xing Yang
    Local abnormal fungi in Caesarean section scar diverticulum can affect the abundance of bacteria through specific metabolites, thereby destroying the stability of bacteria and the entire microbial community.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Scalable, optically-responsive human neuromuscular junction model reveals convergent mechanisms of synaptic dysfunction in familial ALS

    Daniel Chen, Polyxeni Philippidou ... Helen C. Miranda
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Medicine

    Deletion of FNDC5/irisin modifies murine osteocyte function in a sex-specific manner

    Anika Shimonty, Fabrizio Pin ... Lynda F Bonewald
    Analysis of mice lacking the precursor for irisin, FNDC5, provides evidence for a sex-specific role of irisin in calcium release from bone due to osteocytic osteolysis.
    1. Medicine

    Relationship between circulating FSH levels and body composition and bone health in patients with prostate cancer who undergo androgen deprivation therapy: The BLADE study

    Marco Bergamini, Alberto Dalla Volta ... Alfredo Berruti
    Follicle-stimulating hormone in the reference range influences body composition in men exposed to hormone-deprivation therapy for prostate cancer.
    1. Medicine
    2. Microbiology and Infectious Disease

    Altered transcriptomic immune responses of maintenance hemodialysis patients to the COVID-19 mRNA vaccine

    Yi-Shin Chang, Kai Huang ... David L Perkins
    Differing time courses of immune responses to the BTN162b2 mRNA COVID-19 vaccination in maintenance hemodialysis subjects are comparable to healthy controls and identify transcriptomic and clinical predictors of anti-spike IgG titers in hemodialysis subjects.
    1. Medicine

    Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury

    Venkateshwari Varadharajan, Iyappan Ramachandiran ... J Mark Brown
    MBOAT7 loss of function in hepatocytes contributes to ethanol-induced liver injury, offering crucial insights into the dysregulated lipid metabolism and impaired autophagy associated with advanced liver disease.
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