Browse our latest Medicine articles

Page 9 of 61
    1. Medicine
    2. Neuroscience

    Interrogating basal ganglia circuit function in people with Parkinson’s disease and dystonia

    Srdjan Sumarac, Kiah A Spencer ... Luka Milosevic
    The hypo- versus hyperkinetic nature of Parkinson’s disease and dystonia, respectively, may be reflected by differences in disease-specific spiketrain dynamics and striato-pallidal synaptic plasticity.
    1. Medicine

    Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy

    Yohei Nitta, Jiro Osaka ... Atsushi Sugie
    Dominant optic atrophy (DOA) and DOA plus mutations' effects on optic nerve degeneration distinguished in a novel Drosophila model.
    1. Medicine

    A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria

    Tumininu S Faniyan, Xinyi Zhang ... Kavaljit H Chhabra
    Targeting the interaction between the kidneys and brain may increase the efficiency of SGLT2 inhibitors to better manage type 2 diabetes.
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    1. Developmental Biology
    2. Medicine

    SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction

    Stephen E Flaherty III, Olivier Bezy ... Zhidan Wu
    Investigation of mouse models from forward mutagenetic screen reveals that the gene Spag7 is essential for embryonic development and energy homeostasis later in life.
    1. Medicine

    Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity

    Christin Krause, Jan H Britsemmer ... Henriette Kirchner
    The liver microRNA transcriptome of humans with type 2 diabetes and obesity is analyzed for the first time and compared with diet-induced obesity in mice.
    1. Medicine

    Associations of proton pump inhibitors with susceptibility to influenza, pneumonia, and COVID-19: Evidence from a large population-based cohort study

    Ruijie Zeng, Yuying Ma ... Hao Chen
    Proton pump inhibitors are associated with an increased susceptibility to respiratory infections.
    1. Immunology and Inflammation
    2. Medicine

    Anti-inflammatory therapy with nebulized dornase alfa for severe COVID-19 pneumonia: a randomized unblinded trial

    Joanna C Porter, Jamie Inshaw ... Venizelos Papayannopoulos
    Nebulized dornase alfa endonuclease reduces inflammation, coagulopathy, and the length of hospitalization in individuals with severe COVID-19 pneumonia.
    1. Medicine

    An atlas of brain-bone sympathetic neural circuits in mice

    Vitaly Ryu, Anisa Azatovna Gumerova ... Mone Zaidi
    Central SNS outflow sites originating from 87 brain nuclei and sub-nuclei in six brain divisions innervate bone.
    1. Medicine

    Human HPSE2 gene transfer ameliorates bladder pathophysiology in a mutant mouse model of urofacial syndrome

    Filipa M Lopes, Celine Grenier ... Neil A Roberts
    Proof of concept that viral vector-mediated gene transfer improves bladder function in a preclinical model of an inherited early-onset lower urinary tract disease.
    1. Medicine

    Tumor purity-related genes for predicting the prognosis and drug sensitivity of DLBCL patients

    Zhenbang Ye, Ning Huang ... Wenting Huang
    A prognostic model constructed based on RNA-sequencing and clinical specimens analyses reveals VCAN, C1QB, and CD3G could be key factors in modulating tumor microenviornment of DLBCL.