Proof of concept that viral vector-mediated gene transfer improves bladder function in a preclinical model of an inherited early-onset lower urinary tract disease.
A prognostic model constructed based on RNA-sequencing and clinical specimens analyses reveals VCAN, C1QB, and CD3G could be key factors in modulating tumor microenviornment of DLBCL.
The vaginal immunoproteome in pregnancy is more predictive of spontaneous preterm birth (sPTB) than maternal characteristics alone, with sPTB cases showing heightened pro-inflammatory profiles accompanied by reduced levels of antimicrobial proteins/peptides.
Nguyen Lam Vuong, Nguyen Than Ha Quyen ... Ronald Geskus
Higher plasma viremia levels in early dengue and a slower subsequent decline are associated with worse clinical outcomes and provide valuable outcome measures for future therapeutic intervention trials.
Depleting senescent osteoclasts using the senolytic drug Navitoclax (ABT263) can reduce sensory innervation in the endplate and attenuate low back pain, thus representing a potent therapy for treating spinal pain.
Phosphate and calcium from resorbing bone can find their way to the coronary circulation and contribute to atherosclerotic calcification of the blood vessels.
Single-cell RNA sequencing analysis of diabetic mouse cavernous tissue revealed that LBH is a novel pericyte marker and may interact with Crystallin Alpha B and Vimentin to promote neurovascular regeneration.
Matthew F Wipperman, Allen Z Lin ... Olivier Harari
Biosensor data collected by digital insoles is comparable to lab-based clinical assessments and can be used to identify subject-specific gait patterns.
