Browse our latest Medicine articles

Page 11 of 64
    1. Medicine

    Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes

    Jiang Li, Yuefeng Yu ... Bin Wang
    Lipoprotein particle size and composition, fatty acids, and amino acids were associated with the risk of incident diabetes, and adding the selected metabolites could significantly improve the risk prediction of progression from prediabetes to diabetes beyond the conventional clinical variables.
    1. Medicine

    Point of View: Applied research won’t flourish without basic science

    Jon R Lorsch, Lawrence A Tabak, Monica M Bertagnolli
    Three senior figures at the US National Institutes of Health explain why the agency remains committed to supporting basic science and research.
    1. Medicine

    PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy

    Teruhiko Yoshida, Khun Zaw Latt ... Jeffrey B Kopp
    Single-nuclear transcriptomic profiling and functional assays identified PKR activation and mitochondrial dysfunction in HIV-associated nephropathy mice kidneys.
    1. Cancer Biology
    2. Medicine

    Insights into metabolic heterogeneity of colorectal cancer gained from fluorescence lifetime imaging

    Anastasia D Komarova, Snezhana D Sinyushkina ... Marina V Shirmanova
    The level of heterogeneity of cellular energy metabolism increases with model complexity and is the highest in patients' tumors, which can be observed and quantified using FLIM of NAD(P)H.
    1. Medicine

    Serum proteomic profiling of physical activity reveals CD300LG as a novel exerkine with a potential causal link to glucose homeostasis

    Sindre Lee-Ødegård, Marit Hjorth ... Kåre Inge Birkeland
    Long-term physical exercise had a substantial effect on the plasma proteome, identifying novel exerkines and suggesting CD300LG as a potential link to insulin sensitivity.
    1. Medicine
    2. Neuroscience

    Interrogating basal ganglia circuit function in people with Parkinson’s disease and dystonia

    Srdjan Sumarac, Kiah A Spencer ... Luka Milosevic
    The hypo- versus hyperkinetic nature of Parkinson’s disease and dystonia, respectively, may be reflected by differences in disease-specific spiketrain dynamics and striato-pallidal synaptic plasticity.
    1. Medicine

    Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy

    Yohei Nitta, Jiro Osaka ... Atsushi Sugie
    Dominant optic atrophy (DOA) and DOA plus mutations' effects on optic nerve degeneration distinguished in a novel Drosophila model.
    1. Medicine

    A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria

    Tumininu S Faniyan, Xinyi Zhang ... Kavaljit H Chhabra
    Targeting the interaction between the kidneys and brain may increase the efficiency of SGLT2 inhibitors to better manage type 2 diabetes.
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