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Assessing plaque biomechanics by optical coherence tomography highlights the importance of the disrupting effects of plaque stress, bringing stress concentrations as the prime movers of plaque rupture back into clinical practice.

Anti-asprosin monoclonal antibodies, a promising pharmacotherapy for the treatment of metabolic syndrome-associated hyperglycemia, obesity, and dyslipidemia.

Vascular leakage from pathological vessels in retinopathy aggravates the disease, but endothelial junction stability and barrier integrity can be restored by blocking formation of nitric oxide.

Measuring individual differences in noxious-evoked baseline sensitivity in neonates can substantially reduce sample sizes required in neonatal analgesic trials.

Although the ID NOW platform is less sensitive than RT–PCR for identification of SARS-CoV-2 infection, it provides high positive and negative predictive values in low-prevalence populations.

AAV-Txnip prolongs vision in mouse models of blindness, enhancing lactate catabolism, mitochondrial health, and ATP production in a condition that likely has a limited glucose supply.

Transient weakness in myotonia congenita is caused by depolarization secondary to activation of persistent Na⁺ current in skeletal muscle.

Overgrowth of the yeast Pichia kudriavzevii within the neonatal gut microbiota increases allergic airway disease severity later in life and may be inhibited by short-chain fatty acids.

The olfactory mucosa of patients with fatal familial insomnia contains traces of infectious prions, and their analyses could support the clinical diagnosis and elucidate disease-specific mechanisms.

Severe COVID-19 is characterised by a plasma proteomic biomarker signature, indicating innate immune activation, leucocyte–endothelial interactions, and epithelial injury.