A peptide derived from BK and JC polyomavirus protein VP2/3 inhibits viral infection by targeting a binding site in the pore of polyomavirus VP1 pentamers, enabling future VP1-targeted therapeutic strategies.
A coordinated humoral immune response that includes recognition, effector and cytotoxic factors engages the cell-mediated immune response to defend a snail against infection by schistosome parasites.
Unbiased mapping of viral open reading frames (ORFs) and transcripts in HHV-6 genomes uncovers novel ORFs and lncRNAs that are conserved across betaherpesviruses.
Luis V Nobre, Katie Nightingale ... Michael P Weekes
The human cytomegalovirus (HCMV) interactome systematically characterises high-confidence viral-viral and viral-host protein interactions in HCMV-infected cells, facilitating multiple novel insights into HCMV and herpesviral function.
Ivana Strazic Geljic, Paola Kucan Brlic ... Tihana Lenac Rovis
Single mouse cytomegalovirus protein, m154, downmodulates surface expression of numerous targets important for NK and CD8 T cell activation by perturbing adaptor protein-1 sorting and redirecting targets to lysosomal degradation.
Enteroendocrine cells sense nutrients in the gut and regulate digestive physiology but are rendered insensitive following fat ingestion due to alteration of gut microbiota.
Identification of viral and host determinants of broadly neutralizing antibodies targeting a new epitope on dengue virus that can be used to guide vaccine design.
A new study in monkeys suggests that treating HIV infection early with antiretroviral therapy reduces the number of latent viruses, but has little impact on viral reactivation when treatment stops.
Hyung Suk Oh, Werner M Neuhausser ... David M Knipe
CRISPR genome editing technology can efficiently introduce mutations into lytic and latent HSV genomes to block lytic replication and reactivation of latent herpes simplex virus genome though differential mechanisms.
