PriC provides a bypass mechanism for compromised helicase loading at the origin of the Escherichia coli chromosome, which ensures the robustness of the chromosome replication initiation.
Jingbo Kan, Adrian Morales-Amador ... Sean F Brady
Oxydifficidin presents potent activity against multidrug-resistant Neisseria gonorrhea with a new mode of action, which opens a new avenue for potentially addressing antibiotic resistant gonorrhea.
IFN-β-induced WTAP phase transition bridges STAT1 and MTC, which orchestrates m6A dynamics on ISG mRNAs to suppress excessive immune response and sustain immune homeostasis.
Precise protein quality control in the endoplasmic reticulum is crucial for Cryptococcus neoformans pathogenicity by modulating glycoprotein processing and extracellular vesicle-mediated transport of virulence factors.
Marc-Antoine Guery, Sukai Ceesay ... Antoine Claessens
Household clustering and seasonal parasite dynamics highlight the need to target asymptomatic carriers for community-based malaria elimination strategies.