Nelson V Simwela, Eleni Jaecklein ... David G Russell
Prevention of either lipid uptake or lipid catabolism in infected macrophages restricts the ability of Mycobacterium tuberculosis to grow inside these cells.
Gene duplication in antibiotic-resistant bacteria mitigates elevated demand for expression, facilitating adaptation to antibiotics and alleviating costs of proteolytic instability of the drug target.
Structural and functional analyses identify a new family of bifunctional cell-wall-targeting type VI secretion system (T6SS) effectors and a surface-charge-engineering strategy that expands T6SS activity against Gram-positive cells.
Flavia A Zanetti, Ignacio Fernandez ... Laura Ruth Delgui
Molecular, biophysical, and computational analysis reveals insights on the mechanism of association of birnavirus VP3 with endosomes and its role in the viral life cycle, representing a substantial contribution toward understanding the replication strategy of these 'non-canonical' viruses.
In the bacterium M. smegmatis, an enzyme called MftG allows the cofactor mycofactocin to transfer electrons released during ethanol metabolism to the electron transport chain.
Newly produced genomic data, as well as available datasets, reveal the pathogen's global transmission history along with the live poultry trade and pinpoint mobile element-driven local Salmonella adaptation.
Attenuation of viral Nef-driven PI3 kinase signaling in B cells precedes the induction of neutralizing antibody responses against a difficult-to-neutralize simian immunodeficiency virus.
