For the first time, a function for the second messenger molecule, cyclic di-AMP, in Chlamydia has been described, revealing its role in regulating chlamydial developmental cycle progression.
Grafting surface loops containing antibody epitopes of a poorly expressed flu neuraminidase protein onto a high-expressing, stable scaffold improves its production and stability for vaccine development.
In Pseudomonas aeruginosa, the chemoreceptor cluster and flagellar motor colocalize at the same cell pole through FlhF anchoring, preventing cross-pathway signaling interference between chemotaxis and c-di-GMP regulation.
A newly discovered long noncoding RNA lnc-FANCI-2 suppresses RAS signaling to modulate Akt and Erk1/2 phosphorylation in high-risk HPV cervical cancer, consequently regulating HPV carcinogenesis.
Melanie Rose Walker, Preston Leung ... Rowena A Bull
Early immune pressure and co-occurring mutations drive changes in hepatitis C virus fitness and evolution, revealing key dynamics in the establishment of chronic infection.