Browse our latest Microbiology and Infectious Disease articles

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    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Development: Unlocking the microbiome

    Rosana BR Ferreira, L Caetano M Antunes
    Individual species of bacteria and yeast present in the food of wild fruit flies work together to provide the nutrients needed for larval growth.
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    1. Cell Biology
    2. Microbiology and Infectious Disease

    PerTurboID, a targeted in situ method reveals the impact of kinase deletion on its local protein environment in the cytoadhesion complex of malaria-causing parasites

    Heledd Davies, Hugo Belda ... Moritz Treeck
    A new mass spectrometry-based method to identify and quantify changes in a subcellular local protein environment shows the impact of deletion of a kinase the human malaria parasites export into the host cell.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Dissecting the phase separation and oligomerization activities of the carboxysome positioning protein McdB

    Joseph L Basalla, Claudia A Mak ... Anthony G Vecchiarelli
    Carbon-fixing organelles, called carboxysomes, link to their spatial organization system in the bacterial cell by a hexameric protein that forms pH-dependent condensates via a nuanced multidomain mechanism.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A cell wall synthase accelerates plasma membrane partitioning in mycobacteria

    Takehiro Kado, Zarina Akbary ... M Sloan Siegrist
    A newly established reversible model of membrane departitioning and repartitioning in bacteria uncovers the role of a cell wall synthase in regulating membrane partitioning.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    The chemorepellent, SLIT2, bolsters innate immunity against Staphylococcus aureus

    Vikrant K Bhosle, Chunxiang Sun ... Lisa A Robinson
    SLIT2, a prototypic neuro-repellent, spatiotemporally coordinates host defense against Staphylococcus aureus infection by priming neutrophils and stimulating release of reactive oxygen species and secondary and tertiary granules, potently enhancing bactericidal actions of neutrophils.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A tRNA modification in Mycobacterium tuberculosis facilitates optimal intracellular growth

    Francesca G Tomasi, Satoshi Kimura ... Matthew K Waldor
    Surveying Mycobacterium tuberculosis tRNA modification leads to identification of a modification promoting Mtb pathogenesis.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Synchronization of oscillatory growth prepares fungal hyphae for fusion

    Valentin Wernet, Marius Kriegler ... Reinhard Fischer
    Fungal hyphae constantly undergo signal oscillations, comparable to a cell 'monologue' until they meet another hypha with which they then coordinate signal oscillations and transit into a cell-to-cell dialogue.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A CRISPR-based rapid DNA repositioning strategy and the early intranuclear life of HSV-1

    Juan Xiang, Chaoyang Fan ... Pei Xu
    An inducible two-component CRISPR-based platform that rapidly repositions HSV-1 genomes to the nuclear edge unveils intranuclear space heterogeneity for the incoming viral genomes and dynamic stages of the host-virus interplay during early infection.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    A pH-sensitive switch activates virulence in Salmonella

    Dasvit Shetty, Linda J Kenney
    A single conserved residue – histidine 12 – confers pH-sensitive DNA binding to the Salmonella Typhimurium SPI-2 transcriptional regulator SsrB, thereby regulating Salmonella virulence.
    1. Microbiology and Infectious Disease

    Evolution of a functionally intact but antigenically distinct DENV fusion loop

    Rita M Meganck, Deanna Zhu ... Longping V Tse
    Operating as a serum profiling tool for dengue infection and vaccination, the D2-FLM variant, which is insensitive to antibody-dependent enhancement-prone fusion loop antibodies, also offers potential for a safer dengue virus vaccine.
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