Browse our latest Microbiology and Infectious Disease articles

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    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Statistical modeling based on structured surveys of Australian native possum excreta harboring Mycobacterium ulcerans predicts Buruli ulcer occurrence in humans

    Koen Vandelannoote, Andrew H Buultjens ... Timothy P Stinear
    The systematic field testing of excreta from Australian native possums for the bacterial pathogen Mycobacterium ulcerans can be used to build statistical models that predict the regions in southeast Australia where humans will subsequently get Buruli ulcer.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Defining basic rules for hardening influenza A virus liquid condensates

    Temitope Akhigbe Etibor, Silvia Vale-Costa ... Maria-João Amorim
    Thermodynamic, kinetic, and dynamic analyses as well as solubility proteome profiling reveal that influenza A virus liquid inclusions may be selectively hardened with promising antiviral activity.
    1. Microbiology and Infectious Disease

    Functional membrane microdomains and the hydroxamate siderophore transporter ATPase FhuC govern Isd-dependent heme acquisition in Staphylococcus aureus

    Lea Antje Adolf, Angelika Müller-Jochim ... Simon Heilbronner
    Staphylococcal heme acquisition needs a highly structured cell envelope, the membrane transporter accumulates in membrane domains most likely to allow concerted passage of heme from the cell wall-funnel to the membrane.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Rapid geographical source attribution of Salmonella enterica serovar Enteritidis genomes using hierarchical machine learning

    Sion C Bayliss, Rebecca K Locke ... Lauren A Cowley
    Application of hierarchical machine learning to the geographical source attribution of Salmonella enteritidis indicates high utility for the rapid translation of raw pathogen genome sequencing data into accurate and actionable information for disease management in public health.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Increased public health threat of avian-origin H3N2 influenza virus caused by its evolution in dogs

    Mingyue Chen, Yanli Lyu ... Yipeng Sun
    During adaptation in dogs, H3N2 canine influenza viruses (CIVs) became to recognize human-like SAα2,6-Gal receptor, increased replication ability in human cells, acquired a 100% transmission rate via respiratory droplet in ferret model, and human population lacked immunity to H3N2 CIVs.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Viral Condensates: Making it hard to replicate

    Billy Wai-Lung Ng, Stephan Scheeff, Josefina Xeque Amada
    Understanding how to harden liquid condensates produced by influenza A virus could accelerate the development of novel antiviral drugs.
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    Insight
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence

    Pramod K Jangir, Lois Ogunlana ... Craig R MacLean
    Resistance genes that spread as a result of the use of an antimicrobial peptide (colistin) in agriculture (MCR) protect bacteria against key components of human and animal immune systems.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural and regulatory insights into the glideosome-associated connector from Toxoplasma gondii

    Amit Kumar, Oscar Vadas ... Stephen Matthews
    The glideosome-associated connector protein transitions between open and closed states, and this regulates its assembly and function during apicomplexan parasite motility.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Characterisation of an Escherichia coli line that completely lacks ribonucleotide reduction yields insights into the evolution of parasitism and endosymbiosis

    Samantha DM Arras, Nellie Sibaeva ... Anthony M Poole
    An Escherichia coli line lacking deoxyribonucleotide synthesis has been created and subjected to experimental evolution, revealing that endosymbionts and pathogens that lack ribonucleotide reduction avoid loss of deoxyribonucleotides to central metabolism by disruption of the salvage pathway.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    An optimal regulation of fluxes dictates microbial growth in and out of steady state

    Griffin Chure, Jonas Cremer
    Microbial cells optimally structure their proteomes in order to mutually maximize metabolism and translation, as established by an extensive comparison between data and a low-dimensional model of cellular physiology.