Browse our latest Microbiology and Infectious Disease articles

The experimental methods that are routinely used to disperse mycobacterial aggregates markedly impact macrophage infection outcomes, which should be taken into account to appropriately interpret host-pathogen interactions studies.

The ubiquitous second messenger cyclic AMP, produced by Rv3645/MacE, controls long-chain fatty acid metabolism and intrinsic multidrug resistance in M. tuberculosis.

An intravital screen identifies the transcription factors that govern gene expression of the human fungal pathogen Candida albicans during filamentation in a mammalian host.

Targeting nuclear self-antigens to germinal center B cells induces rapid accumulation of follicular regulatory T cells with immunosuppressive phenotype and leads to inhibition of germinal center response with predominant suppression of the nuclear protein-acquiring germinal center B cells.

Patterns of monocyte and dendritic cell mobilization and function during human respiratory viral infections are tissue-specific and pathogen-specific, and future studies must perform comparative investigations in blood and the site of infection for a comprehensive assessment of immune responses.

A combined computational, genetic, and biochemical analysis of the hepatitis E virus open reading frame 1 (ORF1) protein identifies a novel domain-domain interaction that is vital for fitness and supports a proposed structural model of the ORF1 polyprotein.

Some Burkholderia thailandensis strains have evolved a bet-hedging strategy by acquiring insertion sequences positioned such that RecA-dependent homologous recombination between them results in duplication of intervening sequences, which promotes biofilm formation.

Single-cell sequencing of the alveolar bone marrow of apical periodontitis reveals the cellular and molecular composition of the microenvironment and highlights an osteogenic potential within mesenchymal stem cells of inflammatory-related bone diseases.

Spatial transcriptomics analysis of rotavirus replication factories reveals principles of viral transcript partitioning and RNA stoichiometry in these granules.

Hepatitis B virus infection is a neglected challenge among communities who are under-served by conventional models of healthcare, requiring enhanced interventions to reduce inequity.