Browse our latest Microbiology and Infectious Disease articles

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    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Hypoxia-induced tracheal elasticity in vector beetle facilitates the loading of pinewood nematode

    Xuan Tang, Jiao Zhou ... Jianghua Sun
    An insect-transmissible plant pathogen, Bursaphelenchus xylophilus, uniquely excavates hypoxia to increase vector capacity via Muc91C-enhanced elasticity of tracheal tubes.
    1. Microbiology and Infectious Disease

    Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment

    Abdirahman I Abdi, Fiona Achcar ... Matthias Marti
    We investigate how parasites adapt to environmental changes in the context of changing transmission patterns, for example by increasing investment in transmission stages at low endemicity such as elimination settings.
    1. Microbiology and Infectious Disease

    Promoting Fc-Fc interactions between anti-capsular antibodies provides strong immune protection against Streptococcus pneumoniae

    Leire Aguinagalde Salazar, Maurits A den Boer ... Suzan HM Rooijakkers
    Fc engineering of monoclonal antibodies strongly improves immune clearance of pneumococcus.
    1. Microbiology and Infectious Disease

    Viral Replication: Learning more about hepatitis E virus

    Altaira D Dearborn, Ashish Kumar, Joseph Marcotrigiano
    A domain in the ORF1 polyprotein of the hepatitis E virus that was previously thought to be a protease is actually a zinc-binding domain.
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    Insight
    1. Microbiology and Infectious Disease

    Antibiotic-induced accumulation of lipid II synergizes with antimicrobial fatty acids to eradicate bacterial populations

    Ashelyn E Sidders, Katarzyna M Kedziora ... Brian P Conlon
    Palmitoleic acid not only potentiates vancomycin killing of Gram-positive bacteria, but the insertion of palmitoleic acid into the membrane leads to the unexpected accumulation of membrane-bound cell wall precursors, representing a novel mechanism of action for unsaturated fatty acids.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection

    Flora Mikaeloff, Marco Gelpi ... Ujjwal Neogi
    Multi-omics-driven patient stratification identify at-risk profile of metabolic complications in people living with HIV on suppressive therapy that need clinical attention.
    1. Microbiology and Infectious Disease

    Fitness advantage of Bacteroides thetaiotaomicron capsular polysaccharide in the mouse gut depends on the resident microbiota

    Daniel Hoces, Giorgia Greter ... Emma Slack
    Neutral tagging and detailed analysis of bacterial growth kinetics can quantify the mechanisms of colonization resistance in differently colonized animals.
    1. Microbiology and Infectious Disease

    Ribosomal RNA (rRNA) sequences from 33 globally distributed mosquito species for improved metagenomics and species identification

    Cassandra Koh, Lionel Frangeul ... Maria-Carla Saleh
    A score-based read selection strategy enables the assembly of novel full-length ribosomal RNA sequences for mosquitoes, which improves the physical and computational removal of interfering ribosomal RNA reads in RNA-seq and provides another molecular marker for taxonomic and phylogenetic inquiries.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Antibodies to repeat-containing antigens in Plasmodium falciparum are exposure-dependent and short-lived in children in natural malaria infections

    Madhura Raghavan, Katrina L Kalantar ... Joseph L DeRisi
    The dominant targets of host immune response to malaria are repeat elements, which are short stretches of amino acids repeated within Plasmodium falciparum proteins, and these are associated with short-lived and exposure-dependent antibody responses.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Myosin II regulatory light chain phosphorylation and formin availability modulate cytokinesis upon changes in carbohydrate metabolism

    Francisco Prieto-Ruiz, Elisa Gómez-Gil ... José Cansado
    A highly sophisticated and adaptive interplay between modulation of myosin II function by light chain phosphorylation and environmentally controlled formin availability, is critical for a successful cytokinesis during respiratory carbohydrate metabolism in the fission yeast Schizosaccharomyces pombe.