Browse our latest Microbiology and Infectious Disease articles

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    1. Microbiology and Infectious Disease

    Ferric reductase-related proteins mediate fungal heme acquisition

    Udita Roy, Shir Yaish ... Daniel Kornitzer
    A new class of plasma membrane proteins involved in heme-iron utilization provides a molecular link between the extracellular and intracellular parts of the fungal heme acquisition pathway, and reveals the evolutionary origin of this pathway.
    1. Medicine
    2. Microbiology and Infectious Disease

    Novel fast pathogen diagnosis method for severe pneumonia patients in the intensive care unit: randomized clinical trial

    Yan Wang, Xiaohui Liang ... Wenkui Yu
    A novel species-specific detection method could obtain pathogenic bacteria information in 4 hr with high clinical sensitivity and specificity, which guided the faster antibiotic treatment in ICU and brought some clinical benefit in a real-world scenario.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: Multicentre, prospective study

    Oliver Stirrup, James Blackstone ... Judith Breuer
    Sequencing of viral genomes could be useful for infection prevention and control within hospitals, but did not lead to a reduction in the rate of hospital-acquired SARS-CoV-2 infections over winter 2020/2021 in a large multicentre UK study.
    1. Microbiology and Infectious Disease

    Combining transgenesis with paratransgenesis to fight malaria

    Wei Huang, Joel Vega-Rodriguez ... Marcelo Jacobs-Lorena
    The combination of mosquito transgenesis with paratransgenesis provides maximum parasite-blocking activity and has high potential for fighting malaria.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Evolution: A life LINE for large viruses

    Eugene V Koonin, Mart Krupovic
    As long suspected, poxviruses capture host genes through a reverse-transcription process now shown to be mediated by retrotransposons.
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    Insight
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Poxviruses capture host genes by LINE-1 retrotransposition

    Sarah M Fixsen, Kelsey R Cone ... Nels C Elde
    Active selfish genetic elements in infected cells aid virus adaptation by catalyzing the transfer of host genes to virus genomes.
    1. Microbiology and Infectious Disease

    LINE-1 retrotransposons facilitate horizontal gene transfer into poxviruses

    M Julhasur Rahman, Sherry L Haller ... Stefan Rothenburg
    A new experimental system of horizontal gene transfer demonstrates that host retrotransposons facilitate the transfer of host genes into poxviruses.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors

    Hadar Cohen, Noam Baram ... Motti Gerlic
    A horizontally shared type VI secretion system affects the interaction between vibrios and eukaryotic hosts.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Group II truncated haemoglobin YjbI prevents reactive oxygen species-induced protein aggregation in Bacillus subtilis

    Takeshi Imai, Ryuta Tobe ... Hisaaki Mihara
    The repair of oxidatively damaged proteins by the newly discovered activity in YjbI is important for the adaptation of Bacillus subtilis to oxidative environments.
    1. Microbiology and Infectious Disease

    Hemocyte differentiation to the megacyte lineage enhances mosquito immunity against Plasmodium

    Ana Beatriz F Barletta, Banhisikha Saha ... Carolina Barillas-Mury
    Toll signaling modulates hemocyte differentiation into the megacyte lineage and their recruitment to the midgut greatly enhances mosquito immunity against Plasmodium.