Microbiology and Infectious Disease

Microbiology and Infectious Disease

eLife publishes research covering virology, bacteriology and mycology. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Microbiology and Infectious Disease

    c-Myc plays a key role in IFN-γ-induced persistence of Chlamydia trachomatis

    Nadine Vollmuth, Lisa Schlicker ... Thomas Rudel
    The central immune modulator interferon-gamma downregulates the proto-oncogene c-Myc to shut down host cell metabolism and interfere with infection of epithelial cells by obligate intracellular pathogenic Chlamydia trachomatis.
    1. Microbiology and Infectious Disease

    Distinct regions of H. pylori’s bactofilin CcmA regulate protein–protein interactions to control helical cell shape

    Sophie R Sichel, Benjamin P Bratton, Nina R Salama
    The helical cell shape of Helicobacter pylori depends on the polymerizing cytoskeletal protein CcmA’s recruitment to the cell envelope by Csd5 and CcmA’s indirect stabilization of a periplasmic cell wall hydrolase via interactions with the transmembrane protein Csd7.
    1. Microbiology and Infectious Disease

    The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis

    Anne Günther, Matthias Hose ... Wiebke Hansen
    Host cell acid ceramidase activity contributes to the regulation of erythrocyte maturation and thereby affects the frequency of target cells for rodent Plasmodium yoelii parasites.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    The giant mimivirus 1.2 Mb genome is elegantly organized into a 30-nm diameter helical protein shield

    Alejandro Villalta, Alain Schmitt ... Chantal Abergel
    As a Russian doll, mimivirus dsDNA genome is folded in a nucleocapsid-like structure enclosed in the nucleoid compartment, encased in the icosahedral capsid itself decorated by long glycosylated fibrils surprisingly made of the same protein as the genomic fiber.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A mosaic-type trimeric RBD-based COVID-19 vaccine candidate induces potent neutralization against Omicron and other SARS-CoV-2 variants

    Jing Zhang, Zi Bo Han ... Qi Ming Li
    Animal experiments show that the mosaic-type immunogen integrating key mutations from Omicron and other circulating variants elicits broad neutralization against divergent SARS-CoV-2 strains.
    1. Microbiology and Infectious Disease

    Mobilome-driven segregation of the resistome in biological wastewater treatment

    Laura de Nies, Susheel Bhanu Busi ... Paul Wilmes
    1. Microbiology and Infectious Disease

    Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface

    Liheng Yang, Eleanor C Semmes ... Carolyn B Coyne
    Organoids developed from matched human placental tissue define differences in antiviral signaling between cell types comprising the maternal-fetal interface.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Regional importation and asymmetric within-country spread of SARS-CoV-2 variants of concern in the Netherlands

    Alvin X Han, Eva Kozanli ... Chantal Reusken
    Flight restrictions targeted at countries where SARS-CoV-2 variant-of-concern first emerged have limited effectiveness in deterring their introduction into the Netherlands due to the strength of regional travel importation risks in Europe.

Senior editors

  1. Miles P Davenport
    University of New South Wales, Australia
  2. Neil Ferguson
    Imperial College London, United Kingdom
  3. Jos WM van der Meer
    Radboud University Medical Centre, Netherlands
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