Browse our latest Neuroscience articles

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    1. Neuroscience

    Selective transduction and photoinhibition of pre-Bötzinger complex neurons that project to the facial nucleus in rats affects nasofacial activity

    Mariana R Melo, Alexander D Wykes ... Andrew M Allen
    The pre-Bötzinger complex, known as the kernel for the breathing generation, consists of separate subpopulations of neurons that project to specific nuclei to coordinate respiratory rhythmicity with different physiological behaviors, such as nasofacial activity.
    1. Neuroscience

    Conscious processing of global and local auditory irregularities causes differentiated heartbeat-evoked responses

    Diego Candia-Rivera, Federico Raimondo ... Jacobo D Sitt
    Brain-heart interactions under the processing of auditory irregularities could help to distinguish whether a patient is in a vegetative state or in a minimally conscious state.
    1. Neuroscience

    Combined transcranial magnetic stimulation and electroencephalography reveals alterations in cortical excitability during pain

    Nahian Shahmat Chowdhury, Alan KI Chiang ... Siobhan M Schabrun
    Combined TMS-EEG can be used to further elucidate the mechanisms for pain perception and to discover biomarkers for the development of chronic pain.
    1. Neuroscience

    Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens

    Yi He, Yanhua H Huang ... Yan Dong
    Two distinct projections from the basolateral amygdala to nucleus accumbens differentially contribute to cue- versus reward-mediated behavioral reinforcement.
    1. Neuroscience

    Mesotrode allows chronic simultaneous mesoscale cortical imaging and subcortical or peripheral nerve spiking activity recording in mice

    Dongsheng Xiao, Yuhao Yan, Timothy H Murphy
    Low-profile tetrodes that are compatible with wide-field imaging provide the opportunity to evaluate the relationship between spiking neurons and broad networks.
    1. Neuroscience

    Astrocyte and L-lactate in the anterior cingulate cortex modulate schema memory and neuronal mitochondrial biogenesis

    Mastura Akter, Mahadi Hasan ... Ying Li
    Astrocytic Gi pathway activation in the anterior cingulate cortex impairs schema memory and neuronal mitochondrial biogenesis, which can be rescued by exogenous L-lactate administration directly into the area.
    1. Neuroscience

    Approach-avoidance reinforcement learning as a translational and computational model of anxiety-related avoidance

    Yumeya Yamamori, Oliver J Robinson, Jonathan P Roiser
    A computational and translational approach to measuring anxiety-related behaviour was validated in two large independent samples, presenting opportunities for cross-species anxiety research and potential implications for anxiolytic drug development.
    1. Genetics and Genomics
    2. Neuroscience

    Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms

    Yiqiao Zheng, Chi Sun ... Shiming Chen
    The integrated analysis of multi-omics and functional evidence both in vitro and in knock-in mouse models reveal novel gain-of-function pathogenic mechanisms of dominant CRX HD missense mutations.
    1. Neuroscience

    Homeostatic control of deep sleep and molecular correlates of sleep pressure in Drosophila

    Budhaditya Chowdhury, Lakshman Abhilash ... Orie Shafer
    Controlling for the effects of mechanical stimulation during sleep deprivation reveals substantial multi-cycle sleep rebound in Drosophila and reveals serotonin as a potential sleep substance in the fly brain.
    1. Neuroscience

    Smith–Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling

    Sehrish Javed, Ya-Ting Chang ... Wei-Hsiang Huang
    RAI1 regulates molecular signalling and intrinsic excitability of hypothalamic brain-derived neurotrophic factor neurons important for energy homeostasis.