Browse our latest Neuroscience articles

Deletion of Alzheimer’s disease risk gene TREM2 augments sensitivity to the purinergic agonist ADP, leading to increased Ca²⁺ influx and reduced directional migration in human induced pluripotent stem cell-derived microglia.

RNA-binding proteins use both translational activation and repression of key molecular determinants to post-mitotically sculpt the identity and connectivity of developing mouse neocortex in an area-specific manner.

Fetal Zika virus’ direct infection of the brain causes neuroanatomical pathology that tracks with the brain development, following a caudal-to-rostral trajectory, even in individuals who do not develop microcephaly.

Parvalbumin inhibitory neuron-mediated feed-forward inhibition in dentate gyrus-CA3 circuit governs time-dependent re-organization of memory traces in hippocampal-cortical networks to support systems consolidation.

Two-color time-lapse superresolution imaging of the synaptic nanoorganization in vivo uncovers highly dynamic spine heads and PSD95 assemblies that are less variable in size but more dynamic in their PSD95 nanoorganization after environmental enrichment.

NBI-921352 (formerly XEN901) is a precision medicine in development for individuals with SCN8A gain-of-function mutations causing SCN8A related epilepsy syndrome (SCN8A-RES), as well as other epilepsy indications, include adult focal onset seizures (FOS).

Midbrain neurons display attention-related modulation even in the absence of microsaccades, demonstrating that shifts of attention can be dissociated from the generation of microsaccades.

Muscarinic excitation of a previously ignored subtype of periglomerular interneuron in the olfactory bulb by endogenous synaptic release of acetylcholine.

Prediction error responses in layer 2/3 of mouse visual cortex are shaped by experience-dependent modifications of the local cortical circuit.

Surface plasmon resonance studies reveal that clustered protocadherins have precisely tuned trans homophilic binding interactions and promiscuous but variable cis interactions, consistent with the requirement of forming error-free linear molecular zippers used by mammalian neurons to distinguish self from nonself.