Travis A Hage, Alice Bosma-Moody ... Gabe J Murphy
A combination of multicellular recording and optogenetic photostimulation was used to deeply characterize the spatial profiles and effective strengths of intralaminar and translaminar synaptic connections from genetically defined neuronal populations in the visual cortex of adult mouse.
Joseph L Ransdell, Jonathan D Moreno ... Jeanne M Nerbonne
Experimental and modeling results reveal that the activation of resurgent sodium currents relies on the recovery of inactivated channels into a conducting state, and that the decay of resurgent currents reflects the accumulation of these channels into a slow-inactivated state.
The interplay of recurrent excitation and short-term plasticity enables nonlinear transient amplification, an ideal mechanism for selective amplification, pattern completion, and pattern separation in recurrent neural networks.
Combining compartment- and cell-type specific transcriptomic approaches reveals FMRP regulation of synaptic regulators in the dendrites and chromatin regulators in the cell bodies of CA1 neurons.
Aaron L Nichols, Zack Blumenfeld ... Henry A Lester
Pharmacokinetics, the venerable science that measures the dynamics and concentrations an administered drug attains in organs, has been extended to the subcellular level – organelles – by a generalizable new paradigm.
Explicit judgments of agency incorporate uncertainty by reflecting first-order measures of a noisy signal, but they do not correspond to second-order metacognitive measures of the noise in a signal.
