Browse our latest Neuroscience articles

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    1. Neuroscience

    All-trans retinoic acid induces synaptic plasticity in human cortical neurons

    Maximilian Lenz, Pia Kruse ... Andreas Vlachos
    The vitamin A derivative, all-trans retinoic acid, induces protein-synthesis-dependent synaptic plasticity in the human brain.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Kinetic analysis of ASIC1a delineates conformational signaling from proton-sensing domains to the channel gate

    Sabrina Vullo, Nicolas Ambrosio ... Stephan Kellenberger
    Analysis of conformational changes indicates that activation of acid-sensing ion channels involves protonation of diverse extracellular sites and interaction of interdomain loops with the upper ends of transmembrane helices.
    1. Neuroscience

    Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila

    Magda L Atilano, Sebastian Grönke ... Linda Partridge
    Modulation of insulin signalling could be an effective therapeutic approach against hexanucleotide repeat expansion related to c9ALS/FTD neurodegenerative diseases.
    1. Developmental Biology
    2. Neuroscience

    The olfactory critical period is determined by activity-dependent Sema7A/PlxnC1 signaling within glomeruli

    Nobuko Inoue, Hirofumi Nishizumi ... Hitoshi Sakano
    The critical period in the mouse olfactory system is defined by activity-dependent synapse formation induced by Semaphorin7A/PlexinC1 signaling in the neonatal glomeruli.
    1. Neuroscience

    Selective dendritic localization of mRNA in Drosophila mushroom body output neurons

    Jessica Mitchell, Carlas S Smith ... Scott Waddell
    Specific mRNAs localize to the dendrites of Drosophila mushroom body output neurons.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    A KDM5–Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation

    Hayden AM Hatch, Helen M Belalcazar ... Julie Secombe
    The histone demethylase KDM5 functions in concert with the transcription factor Prospero to regulate a gene expression program that is required for mushroom body neuroanatomical development.
    1. Neuroscience

    Design issues and solutions for stop-signal data from the Adolescent Brain Cognitive Development (ABCD) study

    Patrick G Bissett, McKenzie P Hagen ... Russell A Poldrack
    Problematic design features in the stop-signal task for the massive Adolescent Brain Cognitive Development (ABCD) study undermine analyses of the shared data, but can be mitigated with proposed solutions.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Architecture and structural dynamics of the heteromeric GluK2/K5 kainate receptor

    Nandish Khanra, Patricia MGE Brown ... Joel R Meyerson
    Structures of the GluK2/K5 kainate receptor reveal the heteromer architecture and how the receptor organizes in apo, antagonist-bound, and desensitized states.
    1. Neuroscience

    A spinoparabrachial circuit defined by Tacr1 expression drives pain

    Arnab Barik, Anupama Sathyamurthy ... Alexander Chesler
    A circuit involving Tacr1-expressing neurons in the spinal cord and the parabrachial nucleus controls how mice respond to a wide range of persistently painful stimuli.
    1. Neuroscience

    The neural basis of intelligence in fine-grained cortical topographies

    Ma Feilong, J Swaroop Guntupalli, James V Haxby
    Individual differences in intelligence are based on information processing that is embedded in fine-scale structure in cortical systems for self-generated thought, which was revealed by resolving topographic idiosyncrasies with hyperalignment.