APP mutations that either cause or prevent dementia alter APP metabolism in a complex and opposite fashion, suggesting a link between multiple APP processing events, dementia and ageing-dependent cognitive decline.
Samuel A Neymotin, Dylan S Daniels ... Stephanie R Jones
Human Neocortical Neurosolver is a new user-friendly software tool for researchers to develop and test hypotheses on cellular/circuit origins of human MEG/EEG signals using a biophysical model.
Cheng-Hsin Liu, Sharon R Stevens ... Matthew N Rasband
A combination of sensory-neuron specific conditional knockout mice reveal nodal beta spectrins are required to maintain, but not assemble, nodes of Ranvier.
Travis A Babola, Calvin J Kersbergen ... Dwight E Bergles
Supporting cells in the cochlea change their shape in response to purinergic receptor activation, which influences hair cell excitability by altering potassium redistribution in the extracellular space.
Development of nanobodies against a model pentameric ligand-gated ion channel demonstrates they can be functionally active as negative or positive allosteric modulators and offers opportunities for future drug development.
Cell-specific architectural properties such as the axon diameter of the white matter of the human brain can be quantified accurately and non-invasively using diffusion magnetic resonance imaging.
Thibaut Laboute, Jorge Gandía ... Jérôme AJ Becker
GPR88 inhibits G-protein signaling of nearby GPCRs, and dampens b-arrestin recruitment by all GPCRs tested, likely by sequestration in intracellular compartments.
Michael L Wallace, Kee Wui Huang ... Bernardo L Sabatini
Single-cell transcriptional profiling reveals distinct neuronal subtypes of the lateral habenula differentially target downstream neuronal subtypes in the ventral tegmental area and dorsal raphe nucleus.
