Muscarinic acetylcholine receptor type A in adult Drosophila inhibits Kenyon cells, and is required for aversive olfactory learning and learning-associated synaptic depression between Kenyon cells and their output neurons.
Georgios PD Argyropoulos, Clare Loane ... Christopher R Butler
Hippocampal damage is associated with changes across the extended hippocampal system, and these may explain variability in memory between patients presenting with hippocampal amnesia.
Resting-state capillary blood flow and oxygenation are more homogeneous in the deeper cortical layers, underpinning an important mechanism by which the microvascular network adapts to an increased local oxidative metabolism.
Threonine promotes sleep via down-regulation of metabotropic GABA transmission in the ellipsoid body R2 neurons that generate homeostatic sleep drive in Drosophila.
Jesús Rodriguez Curt, Behzad Yaghmaeian Salmani, Stefan Thor
The expansion of the anterior Drosophila CNS is driven by increased progenitor generation and prolonged proliferation, mediated by brain-restricted genes and the PRC2.
Delay-period activity of anterior piriform cortex is important for working memory tasks requiring active maintenance and encodes the maintained information.
Andrea KH Stavoe, Pallavi P Gopal ... Erika LF Holzbaur
The dynamic phosphorylation of autophagy component WIPI2B is critical to maintain autophagosome biogenesis in neurons, and ectopic expression of WIPI2B can restore rates of autophagosome biogenesis in aged neurons.
Vasoactive intestinal peptide-expressing GABAergic interneurons in cerebral cortex express the sodium channel subunit Nav1.1, and a defined subset of VIP interneurons are dysfunctional in a mouse model of Dravet syndrome.
