Browse our latest Neuroscience articles

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    1. Computational and Systems Biology
    2. Neuroscience

    Spike-timing-dependent ensemble encoding by non-classically responsive cortical neurons

    Michele N Insanally, Ioana Carcea ... Robert C Froemke
    During behavior, many neurons do not have classic trial-averaged responses to behaviorally relevant stimuli, but can still have activity and population dynamics related to stimulus and behavioral choice on single trials.
    1. Computational and Systems Biology
    2. Neuroscience

    Bumblebee visual allometry results in locally improved resolution and globally improved sensitivity

    Gavin J Taylor, Pierre Tichit ... Emily Baird
    Bigger bumblebee eyes have better vision, yet their field of view, sensitivity, and resolution do not all simply scale up with eye size, being improved locally instead.
    1. Neuroscience

    Impaired voice processing in reward and salience circuits predicts social communication in children with autism

    Daniel Arthur Abrams, Aarthi Padmanabhan ... Vinod Menon
    Children with autism often 'tune out' the voices in their environment and new results show that impaired processing of voices in the brain's reward system may underlie this social behavior.
    1. Neuroscience

    Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

    Shuo-Chien Ling, Somasish Ghosh Dastidar ... Don W Cleveland
    Elevating FUS level by saturating autoregulation loop in mice causes aggressive motor neuron disease via disrupting protein and RNA homeostasis.
    1. Developmental Biology
    2. Neuroscience

    Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin

    Denise M Poltavski, Pauline Colombier ... Takako Makita
    Second-order guidance, a novel mechanism by which an initial guidance cue controls expression of a second guidance receptor, is required for precise refinement of axon trajectories during PNS development.
    1. Neuroscience

    Heterodimerization of UNC-13/RIM regulates synaptic vesicle release probability but not priming in C. elegans

    Haowen Liu, Lei Li ... Zhitao Hu
    RIM binding UNC-13L C2A domain releases UNC-13L from an autoinhibitory homodimeric complex to become fusion-competent, and regulates probability of synaptic vesicle release in the post-priming process.
    1. Computational and Systems Biology
    2. Neuroscience

    Discovering and deciphering relationships across disparate data modalities

    Joshua T Vogelstein, Eric W Bridgeford ... Cencheng Shen
    Multiscale Graph Correlation, an interpretable hypothesis test with strong theoretical guarantees for discerning relationships in complex data, requires about half the sample size as other methods, whilst maintaining computational tractability.
    1. Developmental Biology
    2. Neuroscience

    Temporal identity establishes columnar neuron morphology, connectivity, and function in a Drosophila navigation circuit

    Luis F Sullivan, Timothy L Warren, Chris Q Doe
    The Eyeless/Pax6 temporal transcription factor generates neuronal identity, connectivity, and flight navigation behavior within the conserved adult brain structure called the central complex.
    1. Developmental Biology
    2. Neuroscience

    The cellular basis of mechanosensory Merkel-cell innervation during development

    Blair A Jenkins, Natalia M Fontecilla ... Ellen A Lumpkin
    Touch-sensitive neurons are patterned during mammalian skin development by placode-derived keratinocytes and Bone Morphogenetic Protein signaling.
    1. Neuroscience

    The impact of pathological high-frequency oscillations on hippocampal network activity in rats with chronic epilepsy

    Laura A Ewell, Kyle B Fischer ... Jill K Leutgeb
    A novel framework for separating normal and pathological high-frequency oscillations in animals with epilepsy uncovers new mechanisms for impaired hippocampal network function.