Browse our latest Neuroscience articles

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    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains

    Huaying Zhao, Suvendu Lomash ... Peter Schuck
    Members of kainate and AMPA families of glutamate receptors exhibit large differences in affinity for homo- and hetero-dimerziation of their amino terminal domains, which may control gating characteristics and ion selectivity of receptor subtypes with different subunit composition.
    1. Neuroscience

    Beyond excitation/inhibition imbalance in multidimensional models of neural circuit changes in brain disorders

    Cian O'Donnell, J Tiago Gonçalves ... Terrence J Sejnowski
    Computational modeling and analysis of mouse neural population data finds that the excitation/inhibition imbalance theory of brain disorders is too limited to account for key changes in neural activity statistics.
    1. Neuroscience

    Action history influences subsequent movement via two distinct processes

    Welber Marinovic, Eugene Poh ... Timothy J Carroll
    Movement biases due to recent action history involve both dynamically-evolving processes reflecting prediction of future actions, and temporally-stable processes induced by movement repetition.
    1. Neuroscience

    Infants are superior in implicit crossmodal learning and use other learning mechanisms than adults

    Sophie Rohlf, Boukje Habets ... Brigitte Röder
    Electrophysiological activity indicates superior implicit crossmodal learning in infants and a change in learning mode from infancy to adulthood.
    1. Neuroscience

    Conserved neural circuit structure across Drosophila larval development revealed by comparative connectomics

    Stephan Gerhard, Ingrid Andrade ... Casey M Schneider-Mizell
    The connectivity structure of a nociceptive circuit is precisely maintained over Drosophila larval development through cell type-specific increases in synaptic contacts as measured from electron microscopy reconstructions, while individual neurons grow five-fold in size and number of synapses.
    1. Computational and Systems Biology
    2. Neuroscience

    Exploratory search during directed navigation in C. elegans and Drosophila larva

    Mason Klein, Sergei V Krivov ... Martin Karplus
    Crawling Drosophila larvae and C. elegans exhibit diffusive behavior alongside directed motion, and the dynamics of this navigation can be analyzed with techniques developed in understanding protein folding, using a Markov state model.
    1. Neuroscience

    Neural computations underlying inverse reinforcement learning in the human brain

    Sven Collette, Wolfgang M Pauli ... John O'Doherty
    The human brain is capable of implementing inverse reinforcement learning, where an observer infers the hidden reward structure of a decision problem solely through observing another individual take actions.
    1. Neuroscience

    The large-scale organization of shape processing in the ventral and dorsal pathways

    Erez Freud, Jody C Culham ... Marlene Behrmann
    Functional neuroimaging reveals sensitivity to shape information and correlation between brain activation and perceptual behaviour in both dorsal and ventral visual pathways, thereby challenging the strict binary distinctions between the two pathways.
    1. Neuroscience

    SynEM, automated synapse detection for connectomics

    Benedikt Staffler, Manuel Berning ... Moritz Helmstaedter
    The detection of chemical synapses in 3-dimensional electron microscopy data has been automated such that synapses in large-scale connectivity maps of the cerebral cortex, connectomes, can be charted without the need for human interaction.
    1. Neuroscience

    Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves

    Miriam Schwalm, Florian Schmid ... Albrecht Stroh
    Locally recorded calcium events related to slow wave activity show a global cortical fMRI BOLD correlate, establishing a direct relation between a basic neurophysiological signal and the macroscopic perspective of pre-clinical fMRI.