Motor training decreased the unit synaptic response and suppressed induction of long-term depression at parallel fiber to Purkinje cell synapses in the cerebellum, supporting involvement of long-term depression in motor learning.
William D Constance, Amrita Mukherjee ... Darren W Williams
Axonal arborisation growth is regulated by dynamic, focal localisations of Neurexin and Neuroligin that provide stability for filopodia, enabling a 'stick and grow'-based mechanism, wholly independent of synapse formation.
A class of interneuron is identified that promotes escape behavior downstream of nociceptor inputs via connections to nociceptive integrator and premotor networks.
Optogenetics and in vivo recordings in mice reveal that pauses in cholinergic interneurons offer an alternative mechanism to inhibit subthreshold and suprathreshold events of spiny projection neurons.
Alexandre Caron, Heather M Dungan Lemko ... Joel K Elmquist
A subset of hypothalamic POMC neurons that express leptin receptors control metabolic responses to changing energy availability including regulating blood glucose and leptin levels.
Jocelyn M Richard, Nakura Stout ... Patricia H Janak
Reward-related cues elicit phasic changes in activity in ventral pallidum neurons, which predict and functionally contribute to the speed of behaviors trained on the basis of act-outcome, but not stimulus-outcome, contingencies.
Luis Alarcon-Martinez, Sinem Yilmaz-Ozcan ... Turgay Dalkara
Pericytes surrounding capillaries in the retina contain α-smooth muscle actin, demonstrating that pericytes have the necessary molecular machinery to change capillary diameter during neurovascular coupling.
Iris IA Groen, Michelle R Greene ... Chris I Baker
Deep network features exhibit a robust correlation with brain activity in scene-selective cortex, but are not sufficient to explain human scene categorization behavior, which is strongly shaped by information about the function (possibility for action) of the scene.
