Hideyuki Matsumoto, Ju Tian ... Mitsuko Watabe-Uchida
Dopamine neurons signal value prediction errors (VPEs) integrating information about both reward and aversion, in low reward contexts, whereas VPEs in some dopamine neurons are distorted in high reward contexts.
Claudia Kathe, Thomas Haynes Hutson ... Lawrence David Falcon Moon
Delayed intramuscular gene therapy with neurotrophin-3 after corticospinal tract injury reduces spasticity and improves locomotion by treating underlying causes of spasticity.
Electron-donating nucleophilic compounds activate TRPA1 ion channels in fruit flies and mosquitoes, but not humans, making TRPA1 a promising target for insect repellants.
MicroRNA-based direct conversion of human fibroblasts to neurons is applicable to fibroblasts from donors ranging in age from neonatal to centenarian, allowing the generation of neurons that maintain the age-associated signatures of the starting fibroblasts.
GABAergic neurons in the nervous system of C. elegans have been comprehensively mapped allowing analysis of regulatory factors that program GABAergic neuron identity.
Johannes Stratmann, Hugo Gabilondo ... Stefan Thor
A combination of temporal and sub-temporal genes combine to move the stem cell through different competence windows to generate different cell types at different time-points in Drosophila.
Axonal metabolic flux analysis demonstrates that expression of NMNAT1 blocks axonal degeneration in cultured mouse neurons not by altering NAD+ synthesis, but rather by inhibiting injury-induced, SARM1-dependent NAD+ consumption.
