Drosophila polymodal nociceptors use precipitous fluctuation of the firing rate, which depends on Ca2+ influx, as a key signal encoding a heat sensation and evoking the robust heat avoidance behavior.
Peer-Hendrik Kuhn, Alessio Vittorio Colombo ... Stefan F Lichtenthaler
The metalloprotease ADAM10 modulates axon and synapse function by cleaving numerous synaptic and axonal membrane proteins in the central nervous system.
Declan G Lyons, Alexandre Parpaleix ... Serge Charpak
Two-photon phosphorescence lifetime microscopy reveals the physiological values of oxygen concentration and blood flow parameters in the brains of awake mice.
Claudia Scheckel, Elodie Drapeau ... Robert B Darnell
Neuronal ELAV-like (nELAVL) proteins are associated with non-coding Y RNAs in stressed neurons and in the brains of Alzheimer's disease patients, suggesting a new means of regulatory protein sequestration and mRNA target regulation.
Laura Pereira, Paschalis Kratsios ... Oliver Hobert
Analyzing a map of all cholinergic neurons in the nematode C. elegans shows how these neurons are embedded in the C. elegans connectome and reveals the regulatory factors controlling their development.
During early cortical development, microRNA-128 regulates the homeostasis of neural stem cells by targeting PCM1, a protein that is critical for cell division.
A novel analysis of neural activity recorded in monkeys performing a “brain-machine interface” task reveals that a mismatch between motor effectors and the brains’ internal models of those effectors can explain a substantial portion of movement errors.
