During aging, microglia progress through intermediate cellular states, including stress response and translation upregulation states, that modulate subsequent activation and impact cognitive decline.
William Hockeimer, Ruo-Yah Lai ... James J Knierim
Place cells that show repeating place fields in geometrically similar locations of an environment modulate their firing rates differently in each field based on movement direction.
To better understand how olfactory ensheathing cells modify spinal cord injury sites, single-cell RNA-sequencing was used to identify five OEC subtypes, progenitors, and novel genes associated with axonal outgrowth.
Novel genetically encoded tools PFE3, paGFE3, and chGFE3 can be used to reversibly ablate excitatory synapses constitutively, and inhibitory synapses in a light- or chemically dependent manner.
Larger dendritic diameter, increased conductance load at the soma, and differences in cable and ion channel properties enable faster signal propagation in human neocortical dendrites, preserving information processing speed.
Franziska Auer, Katherine Nardone ... David Schoppik
Purkinje cells influence postural control in developing zebrafish, revealing age-dependent cerebellar contributions to balance and establishing a powerful model for studying cerebellar control of postural maturation.
