When navigating environments with changing rules, human brain circuits flexibly adapt how and where we retain information to help us achieve our immediate goals.
The distributed network of working memory, encompassing frontal, parietal, and sensory cortices, flexibly reconfigures under different tasks to adapt to varying control demands.
β-CTF of APP, not Aβ, induces synaptic loss in a cell-autonomous manner, revealing APP misregulation may contribute to the pathogenesis of Alzheimer's disease via an Aβ-independent mechanism.
Benjamin Le Gac, Marine Tournissac ... Bruno Cauli
Increased neuronal activity of cortical pyramidal cells can paradoxically reduce cerebral blood flow via vasoconstriction mediated by glutamate and lipid messengers.
Simply crushed zizyphi spinosi semen not only ameliorates Aβ, tau, and α-synuclein pathology in dementia model mice, but also rejuvenates brain function by suppressing cellular senescence in normal aged mice.
Memory tests evoke a second stage of internal attentional deployment following both expected and unexpected memory tests, extending attentional re-orienting to working memory.
Brian DePasquale, Carlos D Brody, Jonathan W Pillow
A computational framework for combining neural and behavioral data to infer latent dynamics underlying decision-making reveals distinct accumulation dynamics in different brain regions in the rat.
