Neuroscience

Latest articles

1. 1. Neuroscience

   One-shot learning and behavioral eligibility traces in sequential decision making

   Marco P Lehmann et al.

   Human learning relies on short-term memories (eligibility traces) which provide a mechanism to reinforce sequences of actions from a single reward (one-shot).
2. 1. Neuroscience

   DeepPoseKit, a software toolkit for fast and robust animal pose estimation using deep learning

   Jacob M Graving et al.

   A new deep-learning software toolkit with general-purpose methods for quickly and reliably measuring the full body posture of animals directly from images or videos without physical markers.
3. 1. Neuroscience

   A Drosophila model of neuronal ceroid lipofuscinosis CLN4 reveals a hypermorphic gain of function mechanism

   Elliot Imler et al.

   Genetic analysis of a CLN4 Drosophila model suggests that the disease-causing alleles act as dominant gain of function mutations that cause CSPα oligomerization and impair secretory and prelysosomal trafficking.
4. 1. Neuroscience

   Neurodegeneration: Fly model sheds light on brain disease

   Martin H Berryer et al.

   Experiments on flies suggest that a gain-of-function mechanism in a protein called CSPɑ contributes to the progressive brain disease CLN4.
5. 1. Developmental Biology
   2. Neuroscience

   Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons

   Max Koppers et al.

   Multiple axonal guidance receptors control the local and selective translation of mRNAs by binding to ribosomes, specific mRNAs and RNA-binding proteins.
6. 1. Neuroscience

   Reliability of an interneuron response depends on an integrated sensory state

   May Dobosiewicz et al.

   A pair of interneurons in C. elegans condenses information from multiple sensory neurons into a uniform response, using an AND-gate logic to represent a stimulus with positive valence.
7. 1. Neuroscience

   Single cell transcriptome atlas of the Drosophila larval brain

   Clarisse Brunet Avalos et al.

   Single-cell transcriptomics identifies cellular composition of the first instar Drosophila brain and the response to starvation.
8. 1. Neuroscience

   High-throughput microcircuit analysis of individual human brains through next-generation multineuron patch-clamp

   Yangfan Peng et al.

   Combining a multineuron patch-clamp system with an automated pipette pressure and cleaning device enables efficient screening of synaptic connectivity in human brain slices and allows inter-individual comparison.
9. 1. Developmental Biology
   2. Neuroscience

   Gradient-independent Wnt signaling instructs asymmetric neurite pruning in C. elegans

   Menghao Lu, Kota Mizumoto

   Genetic analyses revealed the critical role of local Wnt in neuronal patterning by instructing neurite pruning.
10. 1. Neuroscience

    Insights into the dynamic control of breathing revealed through cell-type-specific responses to substance P

    Nathan A Baertsch, Jan-Marino Ramirez