Browse our latest Physics of Living Systems articles

Page 17 of 54
    1. Developmental Biology
    2. Physics of Living Systems

    Cellular compartmentalisation and receptor promiscuity as a strategy for accurate and robust inference of position during morphogenesis

    Krishnan S Iyer, Chaitra Prabhakara ... Madan Rao
    An information theoretic and systems biology approach shows that cellular compartmentalisation and receptor promiscuity can facilitate the accurate and robust inference of position from noisy morphogen profiles, verified by experiments in Drosophila wing imaginal disc.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Gating interactions steer loop conformational changes in the active site of the L1 metallo-β-lactamase

    Zhuoran Zhao, Xiayu Shen ... Shozeb Haider
    Extremely significant interactions between α3-β7 and β12-α5 loops in the tetrameric L1 metallo-β-lactamase play an important role in the structural remodeling of the active site and offer insights into the potential for novel drug development by exploiting these interactions.
    1. Physics of Living Systems

    Nuclear export inhibition jumbles epithelial–mesenchymal states and gives rise to migratory disorder in healthy epithelia

    Carly M Krull, Haiyi Li, Amit Pathak
    Nuclear export inhibition reveals concurrent epithelial and mesenchymal phenotypes that cause mechanosensitive disorder in collectively migrating epithelia.
    1. Physics of Living Systems

    Geometric control of myosin II orientation during axis elongation

    Matthew F Lefebvre, Nikolas H Claussen ... Sebastian J Streichan
    During Drosophila axis elongation, the orientational pattern of the cytoskeleton is in good approximation stationary, while the genes thought to instruct these patterns are transported with the tissue flow.
    1. Cell Biology
    2. Physics of Living Systems

    Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia

    Christa Ringers, Stephan Bialonski ... Nathalie Jurisch-Yaksi
    Novel frequency-based analysis and computation modeling of cilia carpets reveals that tissue-scale metachronal coordination of cilia can arise even in the absence of global synchronization.
    1. Immunology and Inflammation
    2. Physics of Living Systems

    Quantifying changes in the T cell receptor repertoire during thymic development

    Francesco Camaglia, Arie Ryvkin ... Nir Friedman
    Sequence signatures can be used to discriminate between selected and non-selected immune repertoires at different stages only at the collective population level but not at the level of single cells.
    1. Cell Biology
    2. Physics of Living Systems

    Condensates: When fixation creates fiction

    Judith Miné-Hattab
    A chemical regularly used to image cells can dramatically alter the way cellular compartments called condensates look under the microscope.
    Version of Record
    Insight
    1. Neuroscience
    2. Physics of Living Systems

    Scale-free behavioral dynamics directly linked with scale-free cortical dynamics

    Sabrina A Jones, Jacob H Barfield ... Woodrow L Shew
    Complex, multi-scale natural behaviors may arise from subpopulations of neurons in cerebral cortex operating near the tipping point of a phase transition, that is, near criticality.
    1. Neuroscience
    2. Physics of Living Systems

    Gigapixel imaging with a novel multi-camera array microscope

    Eric E Thomson, Mark Harfouche ... Eva A Naumann
    A new multi camera imaging platform simultaneously captures large-area, high-resolution video of unconstrained small model organisms and provides behavioral measurements that span multiple spatial scales.
    1. Physics of Living Systems

    Dynamics of cooperative excavation in ant and robot collectives

    S Ganga Prasath, Souvik Mandal ... L Mahadevan
    Observations of ant excavation from a confining corral, along with theoretical models and synthetic robot experiments show the emergence of cooperation induced by pheromones in a malleable environment that is moulded by and moulds collective behavior.