Coarse-grained modeling of mammalian kinetochore-fiber shapes generated under microneedle manipulation reveals the need for lateral anchorage 1-3 μm from the kinetochore to robustly preserve their orientation in the spindle center, promoting mechanical integrity in the dynamic spindle.
The combination of cellular cryo-electron tomography, biochemistry, and mathematical modeling provides the first integrated structural model of the Alphavirus replication organelle.
Mechanochemical coupling between interfacial force and biosurfactant kinetics can coordinate large-scale material transport in primitive life forms, suggesting a new principle to engineer self-organized microbial communities.
A network of open channels allows cells and molecular cargo to travel from the center to the periphery of lab-grown colonies of Pseudomonas aeruginosa, helping to eradicate competing species.
Arnault H Caillet, Andrew TM Phillips ... Luca Modenese
Validated mathematical relationships between motoneuron morphometric and electrophysiological properties are provided as a tool for neuroscientists and modellers to generate hypotheses for experimental studies investigating currently unreported relationships and build virtual motoneuron profiles with consistent properties for modelling purposes.
Paul Gerald Layague Sanchez, Victoria Mochulska ... Alexander Aulehla
A microfluidic experimental approach combined with dynamical systems theory reveals how to entrain an embryonic oscillator, the segmentation clock, and allows for the quantification of its entrainment properties.
Maximilian AH Jakobs, Assaf Zemel, Kristian Franze
Biased growth of microtubules in the advancing axon tip contributes to the uniform orientation of microtubules in mature axons, which is essential for proper neuronal functioning.
