Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Stem Cells and Regenerative Medicine

    Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair

    Justinn Barr, Maria Elena Gentile ... Andrew E Vaughan
    Influenza-induced pulmonary tuft cells are a heterogenous population and emerge independently of Type 2 and interferon signaling, and do not impact dysplastic epithelial regeneration.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Contribution of Trp63CreERT2-labeled cells to alveolar regeneration is independent of tuft cells

    Huachao Huang, Yinshan Fang ... Jianwen Que
    A population of p63+ Krt5- epithelial cells contribute to alveolar regeneration independent of the presence of ectopic tuft cells following viral infection.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A single cell transcriptional roadmap of human pacemaker cell differentiation

    Alexandra Wiesinger, Jiuru Li ... Harsha D Devalla
    Diversification of human pacemaker subpopulations is directed by WNT and TGFβ signaling.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Early anteroposterior regionalisation of human neural crest is shaped by a pro-mesodermal factor

    Antigoni Gogolou, Celine Souilhol ... Anestis Tsakiridis
    A thorough insight into the previously unrecognised role of a critical developmental regulator known as TBXT in influencing the specification of human trunk neural crest cells, the presumed precursors of the childhood tumour neuroblastoma.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Identification of putative enhancer-like elements predicts regulatory networks active in planarian adult stem cells

    Jakke Neiro, Divya Sridhar ... Aziz Aboobaker
    Predicted gene regulatory networks active in planarians adult stem cells provide testable hypotheses about the control of pluripotency and differentiation in animals.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    The C. elegans gonadal sheath Sh1 cells extend asymmetrically over a differentiating germ cell population in the proliferative zone

    Xin Li, Noor Singh ... Kacy Lynn Gordon
    As Caenorhabditis elegans adult hermaphrodite germ cells leave the stem cell niche, they associate with a pair of somatic gonad cells that were thought to be symmetrical, but that actually take on dramatically different positions in the organ.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Transcriptional heterogeneity and cell cycle regulation as central determinants of Primitive Endoderm priming

    Marta Perera, Silas Boye Nissen ... Joshua M Brickman
    The simultaneous expansion of G1 and acceleration of the cell cycle, while ensuring synchronous inheritance of these properties, progressively induces cell identity in differentiation.
    1. Stem Cells and Regenerative Medicine

    A regeneration-triggered metabolic adaptation is necessary for cell identity transitions and cell cycle re-entry to support blastema formation and bone regeneration

    Ana S Brandão, Jorge Borbinha ... Antonio Jacinto
    Zebrafish caudal fin amputation induces an increase in the glycolytic influx that leads to dedifferentiation of osteoblasts and their re-entry in the cell cycle, which is essential for blastema formation and bone regeneration.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Defining the ultrastructure of the hematopoietic stem cell niche by correlative light and electron microscopy

    Sobhika Agarwala, Keun-Young Kim ... Owen J Tamplin
    Multiple imaging modalities resolved the ultrastructure of single hematopoietic stem cells in their endogenous niche, allowing identification of dopamine beta-hydroxylase positive cells as a functional niche cell type.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Development: Shining a light on hematopoietic stem cells

    Anne Schmidt
    A combination of light and electron microscopy has revealed further details about the location and interactions of hematopoietic stem and progenitor cells.
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