Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    The reciprocal regulation between mitochondrial-associated membranes and Notch signaling in skeletal muscle atrophy

    Yurika Ito, Mari Yamagata ... Takahiko Sato
    The maintenance of proper mitochondrial-associated endoplasmic reticulum membranes is crucial for preventing skeletal muscle atrophy to interact with the Notch signaling pathway.
    1. Stem Cells and Regenerative Medicine

    Human skeletal muscle organoids model fetal myogenesis and sustain uncommitted PAX7 myogenic progenitors

    Lampros Mavrommatis, Hyun-Woo Jeong ... Holm Zaehres
    Skeletal muscle organoids differentiated from human pluripotent stem cells offer a system for investigating myogenesis and satellite cell development with translational potential for muscular dystrophy modeling and therapy development.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Asymmetric inheritance of centrosomes maintains stem cell properties in human neural progenitor cells

    Lars N Royall, Diana Machado ... Annina Denoth-Lippuner
    Genetic birthdating in forebrain organoids shows asymmetric inheritance of centrosomes in human neural progenitor cells, required for proper human neurogenesis.
    1. Stem Cells and Regenerative Medicine

    An in vitro model for vitamin A transport across the human blood–brain barrier

    Chandler B Est, Regina M Murphy
    A human stem cell-derived in vitro model provided novel insights into the mechanisms of retinoid accumulation in, and permeation across, the blood–brain barrier.
    1. Stem Cells and Regenerative Medicine

    Germ Cells: From stem cell to egg cell

    Noor M Kotb, Prashanth Rangan
    Experiments on female fruit flies reveal more about the molecular mechanisms involved as germline stem cells transition to become egg cells.
    Version of Record
    Insight
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Multiomics analyses reveal dynamic bioenergetic pathways and functional remodeling of the heart during intermittent fasting

    Thiruma V Arumugam, Asfa Alli-Shaik ... Jayantha Gunaratne
    Intermittent fasting orchestrates molecular shifts, yielding cardiovascular improvements, revealing novel cardioprotective mechanisms, and suggesting innovative pharmacological strategies for cardiovascular disease prevention and treatment.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Single-cell RNA sequencing reveals cellular and molecular heterogeneity in fibrocartilaginous enthesis formation

    Tao Zhang, Liyang Wan ... Hongbin Lu
    Single-cell RNA sequencing to delineate the comprehensive postnatal RC enthesis growth from as early as postnatal day 1 to postnatal day 56.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Imprinted Dlk1 dosage as a size determinant of the mammalian pituitary gland

    Valeria Scagliotti, Maria Lillina Vignola ... Marika Charalambous
    Pituitary gland size and stem cell number is modulated during early life in the mouse by the imprinted gene Dlk1, which acts in multiple developmental compartments in a dosage-sensitive manner.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    A critical role for heme synthesis and succinate in the regulation of pluripotent states transitions

    Damien Detraux, Marino Caruso ... Patricia Renard
    Accumulation of succinate during the in vitro modeling of embryonic stem cell state transition critically regulate cell fate.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Promoting axon regeneration by inhibiting RNA N6-methyladenosine demethylase ALKBH5

    Dong Wang, Tiemei Zheng ... Bin Yu
    Inhibiting RNA N6-methyladenosine demethylase ALKBH5 promoted axonal regeneration of dorsal root ganglion neurons by regulating stability of Lpin2 mRNA and enhanced the survival and axonal regeneration of retinal ganglion cells.