Browse our latest Stem Cells and Regenerative Medicine articles

Mass spectrometry exposes a post-transcriptionally regulated reduction in protein diversity in hematopoietic stem cells, including a lack of detectable Dnmt3a protein levels despite mRNA levels comparable to progenitors.

Whole mount 3D visualization of macromolecule synthesis with light sheet fluorescence microscopy enables quantitative, multiscale analysis at the organ, cellular, and molecular levels of organization.

The transcription factor RUNX1 marks a distinct lineage of luminal castration-resistant prostate cells established early during development and enriched in the periurethral region of adult mouse prostate.

Macrophage production of MT1-MMP upon MI contributes to adverse cardiac remodeling and worsened function by promoting EndMT via TGFB, suggesting MT1-MMP inhibition as a therapeutic option for patients with MI.

Automated liquid handling, whole mount staining, and clearing allow unbiased 3D quantitation of cell markers in human neural organoids with diameters of up to 1 mm at the single-cell level.

Cellular and molecular analyses reveal how Myogenin controls muscle stem cell quiescence and growth of adult muscle fibres.

Analyses of human stem cells with distinct GATA6 mutations revealed a spectrum of molecular responses that drive isolated congenital heart disease or the co-occurrence of pancreas and diaphragm malformations.

CD107a expression divides osteogenic from adipogenic perivascular precursor cells within human white adipose tissue.

Single-cell analyses identify distinct epithelial populations that are conserved between the adult mouse and human prostate, including populations with properties of multipotent progenitors in organoid formation and tissue reconstitution assays.

Gata3 loss in prostate basal stem/progenitor cells upregulates BMP5 which is necessary and sufficient to sustain full self-renewal potential and its inhibition significantly delays both prostate and skin tumor progression.