Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells

    Wai Hoe Ng, Elizabeth K Johnston ... Xi Ren
    An induced pluripotent stem-cell-based, human heart and lung co-differentiation model reveals their shared signaling requirement and enables investigation of their developmental mutual interaction and tissue boundary formation.
    1. Immunology and Inflammation
    2. Stem Cells and Regenerative Medicine

    Hematopoietic stem and progenitor cells improve survival from sepsis by boosting immunomodulatory cells

    Daniel E Morales-Mantilla, Bailee Kain ... Katherine Y King
    Infusion of hematopoietic stem and progenitor cells rescues mice from lethal Group A streptococcal sepsis.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Transcriptional regulation of neural stem cell expansion in the adult hippocampus

    Nannan Guo, Kelsey D McDermott ... Amar Sahay
    Kruppel-like factor 9 (Klf9) is a transcriptional regulator of neural stem cell expansion in the adult hippocampus.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Characterization of the neurogenic niche in the aging dentate gyrus using iterative immunofluorescence imaging

    John Darby Cole, Jacobo Sarabia del Castillo ... Sebastian Jessberger
    Iterative immunostaining using 4i enables detailed characterization of complex mouse and human tissues.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Therapeutic downregulation of neuronal PAS domain 2 (Npas2) promotes surgical skin wound healing

    Yoichiro Shibuya, Akishige Hokugo ... Reza Jarrahy
    A small molecule compound Dwn1, identified through high-throughput screening using Npas2 as the molecular target, enhances wound healing in a murine incisional wound model.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    iMyoblasts for ex vivo and in vivo investigations of human myogenesis and disease modeling

    Dongsheng Guo, Katelyn Daman ... Charles P Emerson Jr
    iMyoblasts, a novel iPS-derived PAX3 muscle stem cell for gene editing, muscle engraftment, and stem cell therapeutics to treat muscle injury and muscular dystrophies.
    1. Evolutionary Biology
    2. Stem Cells and Regenerative Medicine

    A conserved strategy for inducing appendage regeneration in moon jellyfish, Drosophila, and mice

    Michael J Abrams, Fayth Hui Tan ... Lea Goentoro
    Amino acid and sugar supplement induce appendage/limb regeneration in cnidarians, insects, and mammals.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Neural control of growth and size in the axolotl limb regenerate

    Kaylee M Wells, Kristina Kelley ... Catherine D McCusker
    Signaling from the limb nerves regulates the rate of growth and the overall size of the regenerating limb.
    1. Stem Cells and Regenerative Medicine

    External signals regulate continuous transcriptional states in hematopoietic stem cells

    Eva M Fast, Audrey Sporrij ... Leonard I Zon
    In vivo modulation of the prostaglandin, interferon, or granulocyte colony-stimulating factor pathway induces rapid and specific transcriptional changes in hematopoietic stem cells with significant heterogeneity in the cellular response.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Regeneration: A matter of nerves

    Timothy J Duerr, James R Monaghan
    Regrowing new body parts requires neural input to restore appropriately sized limbs in salamanders.
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