Konstantinos Sousounis, Donald M Bryant ... Jessica L Whited
Experimental manipulation of a core DNA damage response factor and cell-cycle checkpoint regulators reveals a key role for these processes in the progenitor cells that fuel limb regeneration.
Hedgehog-pathway activation in adjacent epithelial and stromal cells, but not in epithelial or stromal cells alone, enables the generation of functional de novo hair follicles in unwounded adult mouse skin.
Ruihua Ma, Angelica S Martínez-Ramírez ... Beatriz Sosa-Pineda
Mouse genetic approaches show that multiple Wnt endothelial sources orchestrate the spatiotemporal distribution of hepatocyte functions during liver maturation and respecify metabolic zonation during liver repair.
Yizhe Tang, Juan Pablo Zuniga-Hertz ... Dongsheng Cai
A subpopulation of multi-secretory hypothalamic stem cells was developed to form 3D spheres for peripheral application against mortality and symptom of a severe diabetes model.
Chen Dong, Mariana Beltcheva ... Thorold W Theunissen
Naive hPSCs can readily give rise to human trophoblast stem cells, thus demonstrating their extraembryonic lineage potential and providing a new model system to study human trophectoderm specification.
Increased expression of Drosophila Tailless (TLX homologue) reverts intermediate progenitors to neural stem cells, inducing tumourigenesis via Asense repression and reflecting mutually exclusive TLX and ASCL1 expression in human glioblastoma.
Infrared laser-mediated gene induction microscopy enables precise single-cell labeling in various tissues of zebrafish, and in vivo visualized single-cell lineage tracing reveals the lineage heterogeneity in hematopoietic endothelial cells.
Aliaksandr Khaminets, Tal Ronnen-Oron ... Heinrich Jasper
Cohesin-regulated 3D genome conformation controls activity of transcription factor Escargot in intestinal stem cells, prevents premature differentiation into enterocytes and maintains intestinal homeostasis.
Hessel Honkoop, Dennis EM de Bakker ... Jeroen Bakkers
Single-cell RNA sequencing reveals Nrg1/ErbB2-induced metabolic reprogramming as a pivotal event for cardiomyocyte proliferation during heart regeneration.
