Arun Sharma, Lauren K Wasson ... Pediatric Cardiac Genomics Consortium
Analyses of human stem cells with distinct GATA6 mutations revealed a spectrum of molecular responses that drive isolated congenital heart disease or the co-occurrence of pancreas and diaphragm malformations.
Laura Crowley, Francesco Cambuli ... Michael M Shen
Single-cell analyses identify distinct epithelial populations that are conserved between the adult mouse and human prostate, including populations with properties of multipotent progenitors in organoid formation and tissue reconstitution assays.
Mathieu Tremblay, Sophie Viala ... Maxime Bouchard
Gata3 loss in prostate basal stem/progenitor cells upregulates BMP5 which is necessary and sufficient to sustain full self-renewal potential and its inhibition significantly delays both prostate and skin tumor progression.
Clytia jellyfish regenerate body shape and organs through a mechanically driven process that coordinates tissue remodeling, localized proliferation, and precursor migration and promotes Wnt signaling at a muscle-based landmark.
The ability of C1q to bind to a variety of receptors has implications for signaling biology, spinal cord injury and, possibly, the evolution of the complement system.
Francisca Benavente, Katja M Piltti ... Aileen Anderson
Complement C1q directly drives the behavior of human neural stem cells via a classical receptor signaling mechanism modulating their capacity for functional integration in vivo.
A previously undetected dynamic cell structure orients the mitotic spindle of germ stem cells and grows over one daughter cell, thus helping to balance niche retention with niche exit.
Madeline G Andrews, Lakshmi Subramanian, Arnold R Kriegstein
mTOR signaling regulates the morphology of a human-enriched neural stem cell population and thus contributes to the radial architecture of the developing human cortex with implications for neurodevelopmental disease.
