Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Stem Cells and Regenerative Medicine

    Neural stem cells induce the formation of their physical niche during organogenesis

    Ali Seleit, Isabel Krämer ... Lazaro Centanin
    A physical niche for neural stem cells is generated by the induction of the immediate skin epithelium, a process triggered by the arrival of neural precursors during sensory organ formation in medaka.
    1. Stem Cells and Regenerative Medicine
    2. Immunology and Inflammation

    Modulation of occluding junctions alters the hematopoietic niche to trigger immune activation

    Rohan J Khadilkar, Wayne Vogl ... Guy Tanentzapf
    Occluding-junctions form a permeability barrier around the hematopoietic niche in Drosophila that controls the production of immune cells in response to infection by shaping the signalling micro-environment produced by the niche.
    1. Stem Cells and Regenerative Medicine

    Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis

    Yuhua Tian, Xianghui Ma ... Zhengquan Yu
    miR-31 drives proliferation of intestinal stem cells, and protects intestinal stem cells against apoptosis both during homeostasis and regeneration in response to ionizing radiation injury, and promotes intestinal tumorigenesis through regulation of multiple signaling pathways.
    1. Stem Cells and Regenerative Medicine

    AIRE is a critical spindle-associated protein in embryonic stem cells

    Bin Gu, Jean-Philippe Lambert ... Janet Rossant
    AIRE played novel roles in the mitosis process in embryonic stem cells and early embryo cells.
    1. Stem Cells and Regenerative Medicine

    Human embryonic lung epithelial tips are multipotent progenitors that can be expanded in vitro as long-term self-renewing organoids

    Marko Z Nikolić, Oriol Caritg ... Emma L Rawlins
    Improved characterisation of human embryonic lung development highlights human-mouse differences and facilitates the development of defined culture conditions for the expansion of self-renewing, multipotent human lung epithelial progenitor cells.
    1. Stem Cells and Regenerative Medicine
    2. Genetics and Genomics

    Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells

    Marie MacLennan, Marta García-Cañadas ... Ian R Adams
    Post-translational regulation of retrotransposons plays a key role in preventing retrotransposon mobilization in the epigenetically dynamic mouse germline.
    1. Stem Cells and Regenerative Medicine

    Organ Development: Tips from the embryonic lung

    Avinash Waghray, Jayaraj Rajagopal
    A new source of progenitor cells can now be used to study hidden aspects of human lung development and pediatric lung disease.
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    1. Stem Cells and Regenerative Medicine

    Cutting Edge: Promoting international collaboration and creativity in doctoral students

    Christopher M Groen, Cormac McGrath ... Natalia Landázuri
    Staff from the Mayo Clinic in the US and the Karolinska Institute in Sweden describe a joint transatlantic course intended to broaden the horizons of the next generation of researchers in the field of regenerative medicine.
    1. Stem Cells and Regenerative Medicine

    Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration

    Wenxuan Liu, Alanna Klose ... Joe V Chakkalakal
    Building on previous work (Liu et al., 2015), it is shown that depletion or rescue of adult skeletal muscle stem cells is sufficient to induce or attenuate age-associated neuromuscular junction deterioration respectively.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Oxidative stress induces stem cell proliferation via TRPA1/RyR-mediated Ca2+ signaling in the Drosophila midgut

    Chiwei Xu, Junjie Luo ... Norbert Perrimon
    In response to tissue damage, reactive oxygen species can be sensed by cation channels TRPA1/RyR to cause increases of cytosolic Ca2+ in intestinal stem cells, activating Ras/MAPK activity and stimulating stem cell proliferation in Drosophila.