Browse our latest Stem Cells and Regenerative Medicine articles

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    1. Stem Cells and Regenerative Medicine

    Stem cells and fluid flow drive cyst formation in an invertebrate excretory organ

    Hanh Thi-Kim Vu, Jochen C Rink ... Alejandro Sánchez Alvarado
    Planarians provide evidence for a common evolutionary origin of vertebrate and invertebrate excretory systems and provide a novel experimental model to study human kidney diseases.
    1. Stem Cells and Regenerative Medicine

    Paracrine Met signaling triggers epithelial–mesenchymal transition in mammary luminal progenitors, affecting their fate

    Amandine Di-Cicco, Valérie Petit ... Marie-Ange Deugnier
    Mammary progenitors identified by a new marker, ICAM-1, undergo epithelial-mesenchymal transition and luminal-to-basal switch in response to paracrine Met activation.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Recurrent turnover of senescent cells during regeneration of a complex structure

    Maximina H Yun, Hongorzul Davaapil, Jeremy P Brockes
    Senescent cells are recurrently induced during limb regeneration in salamanders and subsequently eliminated by a highly efficient mechanism of macrophage-dependent surveillance.
    1. Stem Cells and Regenerative Medicine

    Distinct mechanisms underlie oral vs aboral regeneration in the cnidarian Hydractinia echinata

    Brian Bradshaw, Kerry Thompson, Uri Frank
    Stem cell migration underlies head regeneration in the cnidarian (jellies and their kin) Hydractinia, but the regeneration of other body parts is based on the gradual transformation of one tissue type into another.
    1. Stem Cells and Regenerative Medicine

    Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1

    Bo O Zhou, Lei Ding, Sean J Morrison
    Normal hematopoietic stem and progenitor cells slow the regeneration of their niche after injury to minimize leakage from the niche vasculature.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The polarity protein Baz forms a platform for the centrosome orientation during asymmetric stem cell division in the Drosophila male germline

    Mayu Inaba, Zsolt G Venkei, Yukiko M Yamashita
    The stem cell orientation checkpoint senses the correct orientation of centrosomes via their interactions with a protein called Bazooka.
    1. Stem Cells and Regenerative Medicine

    Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish

    Matthew Gemberling, Ravi Karra ... Kenneth D Poss
    Neuregulin1 is induced upon cardiac injury in adult zebrafish, and is sufficient to drive massive proliferative growth of the heart.
    1. Stem Cells and Regenerative Medicine

    In vitro generation of human pluripotent stem cell derived lung organoids

    Briana R Dye, David R Hill ... Jason R Spence
    Directed differentiation of stem cells can generate ventral-anterior foregut spheroids that can expand into three-dimensional lung organoids with striking structural, cellular and molecular similarities to the human fetal lung.
    1. Stem Cells and Regenerative Medicine

    Bioengineered human myobundles mimic clinical responses of skeletal muscle to drugs

    Lauran Madden, Mark Juhas ... Nenad Bursac
    A novel bioengineered human skeletal muscle model with accurate physiological and pharmacological responses may provide a useful tool for preclinical testing.
    1. Stem Cells and Regenerative Medicine

    Tissue Engineering: Muscling in on the third dimension

    Mohsen Afshar Bakooshli, Penney M Gilbert
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