Browse our latest Structural Biology and Molecular Biophysics articles

Page 134 of 182
    1. Structural Biology and Molecular Biophysics

    Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD

    Yannick Mesrouze, Fedir Bokhovchuk ... Patrick Chène
    A structure-function analysis of the YAP:TEAD interaction permits a thermodynamic mapping of this interface.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Identification of a pre-active conformation of a pentameric channel receptor

    Anaïs Menny, Solène N Lefebvre ... Pierre-Jean Corringer
    Allosteric reorganizations of a bacterial channel receptor are mapped along the protein structure, using the site-directed bimane quenching fluorescence technique, through parallel real-time conformational and electrophysiological recordings.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes

    Ramasubramanian Sundaramoorthy, Amanda L Hughes ... Tom Owen-Hughes
    Structural models of the chromatin remodeling enzyme Chd1 in solution and when bound to chromatin indicate that conformational changes to both the enzyme and the nucleosome occur upon nucleotide dependent engagement.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins

    Aimin Yang, Supansa Pantoom, Yao-Wen Wu
    Legionella effector RavZ evades host autophagy by extracting LC3-PE from the membrane before deconjugation.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Bacterial flagella grow through an injection-diffusion mechanism

    Thibaud T Renault, Anthony O Abraham ... Marc Erhardt
    Single cell, fluorescent microscopy and mathematical modeling reveal how bacterial flagella dynamically assemble outside the cell.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of transcription arrest by coliphage HK022 Nun in an Escherichia coli RNA polymerase elongation complex

    Jin Young Kang, Paul Dominic B Olinares ... Seth A Darst
    Cryo-electron microscopy structures show how coliphage HK022 Nun blocks Escherichia coli RNA polymerase translocation by mediating multiple interactions between the RNA polymerase and nucleic acids.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Kinesin-4 KIF21B is a potent microtubule pausing factor

    Wilhelmina E van Riel, Ankit Rai ... Anna Akhmanova
    Kinesin-4 KIF21B combines a processive motor activity with two non-motor microtubule-binding domains and an autoregulatory region to induce pausing of microtubule plus ends.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of ribosome rescue by ArfA and RF2

    Gabriel Demo, Egor Svidritskiy ... Andrei A Korostelev
    Cryo-EM structures reveal the structural dynamics of ArfA*RF2-mediated rescue of stalled ribosomes.
    1. Structural Biology and Molecular Biophysics

    Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel

    Sandip Basak, Nicolaus Schmandt ... Sudha Chakrapani
    Polyunsaturated fatty acids enhance desensitization in pentameric ligand-gated ion channels.
    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    Membrane Phase Separation: Localizing order to boost signaling

    Štefan Bálint, Michael L Dustin
    B-cell receptors form ordered clusters to recruit kinases and exclude phosphatases.
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