Browse our latest Structural Biology and Molecular Biophysics articles

In the plant circadian clock photoreceptor ZEITLUPE, evolutionarily selected residues distinguish photocycle kinetics and allosteric signal transduction pathways to permit proper circadian timing.

Structure of a pathogen effector complexed to Sorting Nexin 5 reveals an evolutionarily conserved interface that is required for retromer-dependent host restriction.

A new component, CatSper zeta, is required for continuous alignment of the calcium channel along the sperm's tail and is crucial for normal sperm swimming behavior and fertility.

A step of contact establishment preceding stable membrane attachment by palmitoylation is identified.

Building on previous work (Fung et al., 2015), the structures of eight new nuclear export signal (NES) peptides bound to Exportin CRM1 are reported, revealing striking diversity in NES structures, a small conserved secondary structural element, and a CRM1 residue that functions as a selectivity filter.

Structure specific nucleases that act in DNA replication, repair and recombination actively mold their DNA while transforming their own structure to achieve precise cleavage of their cognate DNA and avoid the deleterious cleavage of noncognate DNA.

Biochemical data demonstrate that the conformation of the target site DNA can dramatically modulate the kinetics and directionality of the otherwise isoenergetic transposition reaction of DDE transposases.

The nearly complete architecture of the gigantic 90S precursor of small ribosomal subunit is determined by cryo-EM.

The structure of the promising malaria blood-stage vaccine candidate antigen PfCyRPA and the characterization of a protective epitope are facilitating research on its essential role in parasite invasion, and will guide future epitope-focused vaccine design.

Chlamydia hijacks membrane trafficking proteins of the human host via the cytoplasmic domain of a secreted transmembrane protein.