Browse our latest Structural Biology and Molecular Biophysics articles

PIP₂ inhibits the proton-activated chloride (PAC) channel by selectively stabilizing its desensitized state.

Comparision of current and fluorescent kinetics from P2X7 receptor mutants labeled with the fluorescent amino acid ANAP suggests that the characteristic P2X7 current facilitation involves changes in channel gating rather than interactions or conformational changes of its intracellular ballast domain.

New cryoEM structures reveal how small bacteriophage proteins suppress bacterial immunity.

Rationally designed peptide inhibitors of human voltage-gated channels have transformative potential to define a new class of biologics to treat pain.

Computational methods based on both sequence and structure show evidence that tyrosine kinases are energetically biased to populate the 'DFG-out' type-II inhibitor binding conformation relative to serine/threonine kinases.

New functionality in RELION-4.0 allows convenient structure determination from cryo electron tomography data to resolutions sufficient for de novo atomic modelling.

The ability to accurately predict a protein's structure gives us an entirely new way to annotate the human genome.

Calcium drives interactions for both calcium-binding domains of calmodulin in complex with KCa2.1 peptides and both domains are required for normal channel function.

Laser trap measurements show that mechanical work output from curling protofilaments is enhanced by adding magnesium, and that yeast microtubules generate larger and more energetic working strokes than bovine microtubules.

An example of a deep learning-based strategy to discover novel protein-protein interactions and predict their complex structures at high accuracy.