Browse our latest Structural Biology and Molecular Biophysics articles

The dendrite branching receptor HPO-30 modulates actin dynamics by binding to both WAVE complex and actin filaments.

A colloid fractal cluster model provides a quantitative link between the atomistic features of an intrinsically disordered polypeptide and the spatial organization of the biomolecular condensate it forms.

Cryo-EM structures and molecular dynamics simulations of Cx43 gap junction channel and hemichannel reveal a putative closed state.

The hexametric structures of MCM8/9, revealed through cryo-electron microscopy single particle analysis, provide a foundational understanding of its helicase activity and offer novel insights into its mechanistic role.

Multimodal spectroscopy (smFRET, EPR, SAXS, and SANS) and integrative structural modeling reveal large-scale domain rearrangements in human guanylate binding protein 1 (hGBP1) that are driving forces for the formation of oligomers that enable its biological function in innate immune defense.

Understanding protein kinase regulation by activation loop autophosphorylation depends on a critical assessment of experimental design, execution, and interpretation.

ADP-ribosylation factor-like GTPase 15, an atypical small GTPase, binds to cystathionine-β-synthase-pair domain divalent metal cation transport mediator (CNNM) membrane proteins to inhibit divalent cation efflux by CNNM proteins and influx by transient receptor potential ion channel subfamily M member 7.

Cryo-EM structures of Cys-loop receptor Alpo4 from the thermophilic worm Alvinella pompejana show that a sterol derivative CHAPS binds in and outside of its orthosteric binding site and induces a quaternary twist.

The lysine/glutamic acid/arginine region in chromatin assembly factor (CAF-1) forms a long single alpha-helix DNA-binding domain, facilitating the recognition of tetrasome-length DNA and linking functional domains within the CAF-1 architecture for efficient tetrasome assembly after DNA synthesis.