Browse our latest Structural Biology and Molecular Biophysics articles

Computational methods based on both sequence and structure show evidence that tyrosine kinases are energetically biased to populate the 'DFG-out' type-II inhibitor binding conformation relative to serine/threonine kinases.

New functionality in RELION-4.0 allows convenient structure determination from cryo electron tomography data to resolutions sufficient for de novo atomic modelling.

The ability to accurately predict a protein's structure gives us an entirely new way to annotate the human genome.

Calcium drives interactions for both calcium-binding domains of calmodulin in complex with KCa2.1 peptides and both domains are required for normal channel function.

Laser trap measurements show that mechanical work output from curling protofilaments is enhanced by adding magnesium, and that yeast microtubules generate larger and more energetic working strokes than bovine microtubules.

An example of a deep learning-based strategy to discover novel protein-protein interactions and predict their complex structures at high accuracy.

A new mechanism of receptor desensitization is revealed for the novel proton-activated chloride channel, which plays an important role in physiology and disease associated with acidic pH.

Autoinhibition by long-range intramolecular interactions in the partially disordered dynein intermediate chain is relieved by multivalent interactions of dynein light chains, demonstrating for the first time the dual roles of light chains in dynein assembly and regulation.

The impact of phosphorylation on the dynamics of RAS is considered to find allosteric binding sites on the flat surface of the protein, to which small molecules could bind and perturb the RAS-RAF interaction interface.

Super-resolution microscopy and single particle tracking analysis of Piezo1 in red blood cells demonstrate its ability to sense membrane curvature, consistent with a force-through-membrane mechanism of channel mechanosensation in these cells.