Browse our latest Structural Biology and Molecular Biophysics articles

A critical role of aCT in the distinct activation mechanism of insulin receptor and insulin-like growth factor 1 receptor.

Structural analysis of the mitoribosomal small subunit with streptomycin reveals the molecular basis for antibiotic binding and new physiological components such as FeS clusters that assemble between mitochondria specific proteins.

Understanding the mechanism by which streptomycin binds to the small subunit of the mitoribosome may help researchers design less toxic derivatives of this antibiotic.

Integrating co-evolution with long-range dynamic coupling analysis allows to identify allosteric mutations that modulate binding affinity, and this approach can be used to design lectins with enhanced binding affinity.

Integrating a cryogenic light microscope with a focused ion beam/scanning electron microscope, allows directly targeting of fluorescent structure when preparing a frozen-hydrated lamella, without the need for repositioning or fiducial markers.

Cryo-electron microscopy can be used to detect biomolecules in entire 100- to 250-nm-thick cell slices when using a method to collect montages that prevents radiation damage in areas that have not been imaged yet.

A cryo-EM structure of TMEM87A unexpectedly reveals it is structurally related to seven other proteins including Wntless, a chaperone for lipidated and secreted Wnt morphogens, suggesting GOLD-domain seven-transmembrane helix (GOST) proteins may all similarly traffic membrane-associated cargo.

The cryo-EM structure of a functional human NOX2-p22 complex in nanodisc in the resting state reveals the architecture of this key enzyme essential for innate immunity.

SIMC1 and SLF1 bind exclusively to SLF2 to form two separate complexes that direct the human SMC5/6 complex to its antiviral defense or DNA lesion repair activities.

Molecular dynamics simulations reveal the formation of membrane pores by gasdermin-D, the ultimate effector of pyroptotic cell death in inflammation and infection.